| PD-L1抑制剂对非小细胞肺癌小鼠血清IL-4、IFN-γ及生存率的影响 |
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| 引用本文： | 程建猛.PD-L1抑制剂对非小细胞肺癌小鼠血清IL-4、IFN-γ及生存率的影响[J].现代肿瘤医学,2020,0(15):2574-2578. |
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| 作者姓名： | 程建猛 |
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| 作者单位： | 江苏省涟水县人民医院呼吸科，江苏 淮安 223400 |
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| 摘 要： | 目的:分析程序性细胞死亡蛋白配体-1（PD-L1）抑制剂对非小细胞肺癌（NSCLC）小鼠血清白细胞介素-4（IL-4）、干扰素-γ(IFN-γ)及生存的影响。方法:将20只重量16～20 g小鼠随机分为对照组、实验组各10只，对照组在制备NSCLC荷瘤鼠模型后注射0.9%氯化钠溶液，实验组在制备NSCLC荷瘤鼠模型后注射PD-L1抑制剂尼伏单抗，均连续注射4周，测定其体积大小、肿瘤抑制率与血清IL-4、IFN-γ变化，并记录小鼠生存率、生存时间。结果:注射前、注射3 d两组小鼠肿瘤体积比较差异无统计学意义（P>0.05），注射1周、2周、3周、4周实验组肿瘤体积均低于对照组（P<0.05），尤其在注射2～3周时实验组肿瘤体积抑制率基本达最大值；注射1周、2周、3周、4周实验组血清IL-4、IFN-γ水平明显高于对照组（P<0.05）；注射4周实验组生存率高于对照组，实验组平均生存时间较对照组长（P<0.05），注射1周、2周、3周两组生存率比较差异无统计学意义（P>0.05）。结论:PD-L1抑制剂能抑制NSCLC小鼠生长，可能通过上调其血清IL-4、IFN-γ水平而延长小鼠生存时间。
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| 关 键 词： | PD-L1抑制剂 非小细胞肺癌 小鼠 血清IL-4 IFN-γ 生存 |
Effects of PD-L1 inhibitors on serum IL-4，IFN-γ and survival of mice with non-small cell lung cancer |
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| Cheng Jianmeng.Effects of PD-L1 inhibitors on serum IL-4，IFN-γ and survival of mice with non-small cell lung cancer[J].Journal of Modern Oncology,2020,0(15):2574-2578. |
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| Authors: | Cheng Jianmeng |
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| Affiliation: | Department of Respiration，Lianshui County People's Hospital，Jiangsu Huai'an 223400，China. |
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| Abstract: | Objective:To analyze the effects of programmed cell death protein ligand-1(PD-L1）inhibitors on serum interleukin-4(IL-4)，interferon-γ(IFN-γ）and survival of mice with non-small cell lung cancer(NSCLC).Methods:Twenty mice with weight within 16~20 g were randomly divided into the control group and the experimental group，10 mice in each group.0.9% sodium chloride solution was injected after preparing tumor-bearing mouse models of NSCLC in the control group.PD-L1 inhibitor Nivolumab was injected after preparing tumor-bearing mouse models of NSCLC in the experimental group.The injection in both groups lasted for 4 weeks.The volume，tumor inhibition rate and changes of serum IL-4 and IFN-γ were measured.And the survival rate and survival time of the mice were recorded.Results:There was no significant difference in tumor volume between the two groups before injection and after 3 days of injection(P>0.05).The tumor volume of the experimental group was smaller than that of the control group after 1 week，2 weeks，3 weeks and 4 weeks of injection(P<0.05).In particular，the tumor volume inhibition rate reached a maximum after 2 to 3 weeks of injection in the experimental group.Serum IL-4 and IFN-γ levels in the experimental group were significantly higher than those in the control group after 1 week，2 weeks，3 weeks and 4 weeks of injection(P<0.05).The survival rate of the experimental group was higher than that of the control group and the average survival time was longer than the control group after 4 weeks of injection(P<0.05).There was no significant difference in the survival rate between the two groups after 1 week，2 weeks and 3 weeks of injection (P>0.05).Conclusion:PD-L1 inhibitor can inhibit the growth of mice with NSCLC.The survival time may prolong by up-regulating the levels of serum IL-4 and IFN-γ. |
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| Keywords: | PD-L1 inhibitor non-small cell lung cancer mouse serum IL-4 IFN-γ survival |
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