| 肾母细胞瘤MIB－1(Ki－67增殖指数)和p27kip1表达及与预后的关系 |
| |
| 引用本文： | 黄垂名. 肾母细胞瘤MIB－1(Ki－67增殖指数)和p27kip1表达及与预后的关系[J]. 现代肿瘤医学, 2020, 0(12): 2099-2102. DOI: 10.3969/j.issn.1672-4992.2020.12.023 |
| |
| 作者姓名： | 黄垂名 |
| |
| 作者单位： | 海南省人民医院,海南 海口 570100 |
| |
| 摘 要： | 目的:探讨肾母细胞瘤MIB－1 (Ki－67增殖指数)和细胞周期蛋白依赖性激酶抑制剂p27kip1 的表达及与预后的关系.方法:经医院伦理委员会批准,连续纳入2008 年1 月至2013 年8 月在我院就诊的肾母细胞瘤患者样本作为研究对象,观察p27kip1 和MIB－1 阳性表达与患者临床特征的关系.结果:肿瘤组织中...
|
| 关 键 词： | 肾母细胞瘤 Ki－67增殖指数 细胞周期蛋白依赖性激酶抑制剂 |
Expression of nephroblastoma MIB-1 (Ki-67 proliferation index) and cyclin-dependent kinase inhibitor p27kip1 and their relationship with prognosis |
| |
| Huang Chuiming. Expression of nephroblastoma MIB-1 (Ki-67 proliferation index) and cyclin-dependent kinase inhibitor p27kip1 and their relationship with prognosis[J]. Journal of Modern Oncology, 2020, 0(12): 2099-2102. DOI: 10.3969/j.issn.1672-4992.2020.12.023 |
| |
| Authors: | Huang Chuiming |
| |
| Affiliation: | Hainan Provincial People's Hospital,Hainan Haikou 570100,China. |
| |
| Abstract: | Objective:To investigate the expression of MIB-1 (Ki-67 proliferation index) and cyclin-dependent kinase inhibitor p27kip1 in nephroblastoma and their relationship with prognosis.Methods:The samples of patients with nephroblastoma who were admitted to our hospital from January 2008 to August 2013 and approved by the hospital ethics committee were included as subjects.The relationship between the positive expression of p27kip1 and MIB-1 and clinical data was observed.Results:The positive expression rate of MIB-1 in tumor tissues was higher than that in normal kidney tissues.The positive expression rate of p27kip1 was lower than that in normal kidney tissues (P＜0.05).There was no correlation between MIB-1 and p27kip1 expression and gender,age,pathological type and location (P＞0.05),and there was a correlation with clinical stage (P＜0.05).The median survival time of patients with positive MIB-1 expression was lower than that of patients with negative expression,while the median survival time of patients with negative expression of p27kip1 was lower than that of patients with positive expression (P=0.008,0.000).Conclusion:The increased expression of MIB-1 and the decrease of p27kip1 expression are closely related to the occurrence,development and prognosis of nephroblastoma.The clinical intervention should be based on its expression to improve the prognosis of patients. |
| |
| Keywords: | nephroblastoma Ki-67 proliferation index cyclin-dependent kinase inhibitor |
|
| 点击此处可从《现代肿瘤医学》浏览原始摘要信息 |
|
点击此处可从《现代肿瘤医学》下载免费的PDF全文 |
