| TPD52L2基因在肝癌组织中的表达及其价值:基于TCGA数据的分析 |
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| 引用本文： | 吴 虹,韩 咏,牛 坚,黄家利,刘宜翔,王 梦.TPD52L2基因在肝癌组织中的表达及其价值:基于TCGA数据的分析[J].现代肿瘤医学,2020,0(20):3565-3570. |
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| 作者姓名： | 吴 虹 韩 咏 牛 坚 黄家利 刘宜翔 王 梦 |
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| 作者单位： | 1.徐州医科大学附属医院普通外科，江苏 徐州 221002;
2.连云港市市立东方医院，江苏 连云港 222042 |
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| 基金项目： | 江苏省自然科学基金（编号:BK20161176）；江苏省六大人才高峰（编号:WSW-073） |
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| 摘 要： | 目的:探讨TPD52L2（TPD54）基因在肝细胞肝癌（HCC）组织中的表达及价值。方法:下载癌症基因组图谱(TCGA)的公开数据，评估TPD52L2在HCC中的作用。采用Wilcoxon signed-rank检验和Logistic回归分析TPD52L2表达与HCC临床病理特征的关系。采用Cox回归和Kaplan-Meier生存分析HCC患者的临床病理特征与总生存期的关系。利用基因集富集分析(GSEA)方法预测调控通路。结果:HCC组织中TPD52L2的高表达与高分期、高分级、T分期及致癌因素相关（P＜0.05）。Kaplan-Meier生存分析显示，TPD52L2高表达的HCC患者预后比低表达的差（P=0.002）。单因素分析提示，TPD52L2高表达与较差的总体生存率（OS）显著相关（HR:1.04，95%CI:1.02~1.06，P=0.000）;多因素分析显示TPD52L2表达和伴瘤生存是OS的两个独立预后因子。GSEA预测出剪接体通路、嘧啶代谢、RNA降解、细胞周期、WNT信号通路和凋亡通路在TPD52L2高表达中均有不同程度的富集。结论:TPD52L2可能是HCC不良预后的潜在生物标志物，而剪接体通路、嘧啶代谢、RNA降解可能是HCC中TPD52L2调控的关键通路。
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| 关 键 词： | TPD52L2 肝细胞肝癌 癌症基因组图谱 |
Analysis of the expression and value of TPD52L2 in hepatocellular carcinoma tissues:A study based on TCGA data |
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| Wu Hong,Han Yong,Niu Jian,Huang Jiali,Liu Yixiang,Wang Meng.Analysis of the expression and value of TPD52L2 in hepatocellular carcinoma tissues:A study based on TCGA data[J].Journal of Modern Oncology,2020,0(20):3565-3570. |
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| Authors: | Wu Hong Han Yong Niu Jian Huang Jiali Liu Yixiang Wang Meng |
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| Affiliation: | 1.General Surgery Department,Affiliated Hospital of Xuzhou Medical University,Jiangsu Xuzhou 221002,China;2.Lianyungang Municipal Oriental Hospital,Jiangsu Lianyungang 222042,China. |
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| Abstract: | Objective:To investigate the expression and value of TPD52L2（TPD54） gene in hepatocellular carcinoma.Methods:Public data of The Cancer Genome Atlas(TCGA) were downloaded to evaluate the role of TPD52L2 in hepatocellular carcinoma(HCC).Wilcoxon signed-rank test and logistic regression were used to analyze the relationship between TPD52L2 and clinicopathological characteristics.Cox regression and Kaplan-Meier survival analysis were used to analyze the relationship between clinicopathological characteristics and total survival of HCC patients.Results:The high expression of TPD52L2 in HCC was associated with high stage,high grade,T classification and carcinogen(P＜0.05).Kaplan-Meier survival analysis showed that HCC patients with high TPD52L2 expression had a worse prognosis than those with low TPD52L2 expression(P=0.002).Univariate analysis suggested that high expression of TPD52L2 was significantly associated with poor overall survival(OS)(HR:1.04,95%CI:1.02~1.06,P=0.000).Multivariate analysis showed that TPD52L2 expression and tumor survival were two independent prognostic factors for OS.GSEA predicted that the spliceosome pathway,pyrimidine metabolism,RNA degradation,cell cycle,WNT signaling pathway and apoptosis pathway were enriched to different degrees in the high expression of TPD52L2.Conclusion:TPD52L2 may be a potential marker for poor prognosis of HCC,and spliceosome pathway,pyrimidine metabolism,and RNA degradation may be key pathways regulating TPD52L2 in HCC. |
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| Keywords: | TPD52L2 hepatocellular carcinoma TCGA |
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