| 桥本甲状腺炎与甲状腺乳头状癌临床病理特征的相关性分析 |
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| 引用本文： | 邢宝迪,赵宇航,余霄龙,王 越,申宝明,赵文娟.桥本甲状腺炎与甲状腺乳头状癌临床病理特征的相关性分析[J].现代肿瘤医学,2020,0(22):3873-3877. |
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| 作者姓名： | 邢宝迪 赵宇航 余霄龙 王 越 申宝明 赵文娟 |
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| 作者单位： | 1.青岛大学附属医院内分泌与代谢病科，山东 青岛 266003;
2.青岛西海岸新区中心医院内分泌科，山东 青岛 266035;
3.青岛大学附属医院信息管理部，山东 青岛 266003 |
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| 基金项目： | 山东省自然科学基金(编号:ZR2016HM29) |
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| 摘 要： | 目的:探讨桥本甲状腺炎（Hashimoto's thyroiditis,HT）对甲状腺乳头状癌（papillary thyroid carcinoma,PTC）的影响。方法:分析882例经甲状腺切除术且病理证实为PTC患者的临床资料，比较PTC合并HT和非合并HT患者临床病理特征和甲状腺功能，分析HT与PTC临床病理特征的相关性。结果:PTC合并HT组239例（27.10%），非合并HT组643例（72.90%），两组间比较，合并HT组女性、癌灶多发、双侧及淋巴结转移比例显著高于非合并HT组，差异均有统计学意义（均P＜0.05），而年龄、原发灶直径、远处转移、复发危险度分层及TNM分期均无显著性差异（均P＞0.05）。与非合并HT组相比，PTC合并HT组TPOAb、TGAb、TSH水平升高，FT4、FT3水平降低（均P＜0.05）。分别进行Logistic回归分析显示:HT与女性、癌灶多发、淋巴结转移呈独立相关（OR值分别为2.690、1.491、1.514，均P＜0.05）；癌灶多发、原发灶直径>1 cm、合并HT与PTC淋巴结转移独立相关（OR值分别为2.150、2.751、1.465，均P＜0.05）。结论:合并HT的PTC患者女性、多灶及淋巴结转移多见，但不影响预后；癌灶多发、原发灶直径>1 cm、合并HT是PTC淋巴结转移的独立危险因素。
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| 关 键 词： | 桥本甲状腺炎 甲状腺乳头状癌 临床病理特征 |
Correlation analysis between Hashimoto's thyroiditis and clinicopathological features of papillary thyroid carcinoma |
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| XING Baodi,ZHAO Yuhang,YU Xiaolong,WANG Yue,SHEN Baoming,ZHAO Wenjuan.Correlation analysis between Hashimoto's thyroiditis and clinicopathological features of papillary thyroid carcinoma[J].Journal of Modern Oncology,2020,0(22):3873-3877. |
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| Authors: | XING Baodi ZHAO Yuhang YU Xiaolong WANG Yue SHEN Baoming ZHAO Wenjuan |
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| Affiliation: | 1.Department of Endocrinology and Metabolism,the Affiliated Hospital of Qingdao University,Shandong Qingdao 266003,China;2.Department of Endocrinology,West Coast Central Hospital,Shandong Qingdao 266035,China;3.Department of Information Management,the Affiliated Hospital of Qingdao University,Shandong Qingdao 266003,China. |
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| Abstract: | Objective:To investigate the effect of Hashimoto's thyroiditis(HT) on papillary thyroid carcinoma(PTC).Methods:The clinical data of 882 patients with thyroidectomy and pathologically confirmed PTC were analyzed to compare the clinicopathological characteristics and thyroid function differences of PTC patients with HT and non-HT patients,and further analyze the correlation between HT and PTC clinicopathological characteristics.Results:There were 239 patients(27.10%) in the PTC combined with HT group and 643 patients(72.90%) in the non-HT group.The proportion of women,multiple cancerous lesions,bilateral and lymph node metastasis in the HT group was significantly higher than that in the non-HT group(all P＜0.05),but no statistically significant difference in age,tumor diameter,number,distant metastasis and recurrence risk stratification,and TNM staging(all P>0.05).Compared with the non-HT group,the TPOAb,TGAb and TSH levels in the PTC combined HT group increased,while the FT4 and FT3 levels decreased(all P＜0.05).Logistic regression analysis showed that HT was independently correlated with female,multiple cancer foci and lymph node metastasis(OR values were 2.690,1.491 and 1.514,all P＜0.05).Multiple cancer foci,>1 cm in tumor diameter,HT had independent correlation with PTC lymph node metastasis(OR values were 2.150,2.751,1.465,all P＜0.05).Conclusion:Female,multiple foci and lymph node metastasis were common in PTC patients with HT,but the prognosis was not affected.Multiple cancer foci,>1 cm in tumor diameter,and HT were independent risk factors for PTC lymph node metastasis. |
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| Keywords: | Hashimoto's thyroiditis papillary thyroid carcinoma clinicopathological features |
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