| Bmi-1基因与肿瘤多药耐药性的关系 |
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| 引用本文： | 张超,杨春辉综述,孟秀香审校.Bmi-1基因与肿瘤多药耐药性的关系[J].实用肿瘤学杂志,2013,27(4):367-371. |
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| 作者姓名： | 张超 杨春辉综述 孟秀香审校 |
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| 作者单位： | 大连医科大学检验医学院(大连 116044) |
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| 摘 要： | 肿瘤干细胞不仅是肿瘤细胞恶性增殖的来源, 也是肿瘤化疗抵抗和复发的根源。肿瘤干细胞对多种化疗药物耐受是基于其干细胞特性。Bmi-1基因是调控干细胞自我更新和增殖活性的关键因素, 和多种恶性肿瘤的发生密切相关。众多研究结果显示, Bmi-1基因可上调ABC转运蛋白的表达量、抑制细胞凋亡, 通过多种途径介导肿瘤的多药耐药性。本文就Bmi-1基因与肿瘤多药耐药性关系研究进展进行综述。
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| 收稿时间： | 2013-05-20 |
The relationship between Bmi-1 gene and multidrug resistance |
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| ZHANG Chao,YANG Chunhui,MENG Xiuxiang.The relationship between Bmi-1 gene and multidrug resistance[J].Journal of Practical Oncology,2013,27(4):367-371. |
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| Authors: | ZHANG Chao YANG Chunhui MENG Xiuxiang |
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| Affiliation: | College of Laboratory Medicine, Dalian Medical University, Dalian 116044, China |
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| Abstract: | Tumor stem cells are thought to sustain tumor proliferation, chemoresistance and recurrence after therapy.The chemoresistance of tumor stem cells are due to their stem cell properties.Bmi-1 gene plays an important role in self-renewal and proliferation of stem cells, and is associated with a number of malignancies.Bmi-1 gene is reported to display chemoresistance through upregulation of ABC-transporter family, inhibition of cell apoptosis and many other mechanisms.In this review, we make a summary of research advancement on the relationship between Bmi-1 gene and multi drug resistance. |
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