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| PI3K/Akt和AMPK信号通路在运动诱导的啮齿动物骨骼肌内GLUT4转位和表达中的作用 | |
| 引用本文： | 张云丽,王林,刘铁民. PI3K/Akt和AMPK信号通路在运动诱导的啮齿动物骨骼肌内GLUT4转位和表达中的作用[J]. 实验动物与比较医学, 2017, 0(1): 76-82. DOI: 10.3969/j.issn.1674-5817.2017.01.017 |
| 作者姓名： | 张云丽 王林 刘铁民 |
| 作者单位： | 聊城大学体育学院,聊城,252059 |
| 基金项目： | 山东省自然科学基金资助项目(ZR2011CM040) |
| 摘 要： | 骨骼肌在葡萄糖稳态中扮演重要作用,葡萄糖转运体4(glucose transporter4,GLUT4)作为骨骼肌内最主要的葡萄糖转运蛋白,其转位和表达的变化与胰岛素抵抗的发生密切相关.本文综述了近年来关于啮齿动物骨骼肌内GLUT4转位和表达的运动激活以及磷脂酰肌醇-3-激酶(phosphatidylinositol 3-kinases,PI3K)/蛋白激酶B(protein kinase B,Akt)和腺苷酸活化蛋白激酶(AMP-activated protein kinase,AMPK)信号通路介导运动改善骨骼肌葡萄糖摄取的研究进展,旨在为全面了解和明确运动影响啮齿动物骨骼肌内GLUT4转位和表达的机制. |
| 关 键 词： | 骨骼肌 运动 胰岛素抵抗 葡萄糖转运体4(GLUT4) 磷脂酰肌醇-3-激酶(PI3K) 蛋白激酶B(Akt) 腺苷酸活化蛋白激酶(AMPK) |
PI3K/Akt and AMPK Signaling Pathway and Effect of Exercise on Rodent Skeletal Muscle GLUT4 Translocation and Expression |
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| ZHANG Yun-li,WANG Lin,LIU Tie-min. PI3K/Akt and AMPK Signaling Pathway and Effect of Exercise on Rodent Skeletal Muscle GLUT4 Translocation and Expression[J]. Laboratory Animal and Comparative Medicine, 2017, 0(1): 76-82. DOI: 10.3969/j.issn.1674-5817.2017.01.017 | |
| Authors: | ZHANG Yun-li WANG Lin LIU Tie-min |
| Abstract: | Skeletal muscles play an important role in glucose homeostasis.The translocation and expression changes of glucose transporter 4 (GLUT4) as one of the most important glucose transporter proteins in skeletal muscle are closely associated with insulin resistance.This paper reviewed the recent research progress on the exercise-induced translocation and expression of GLUT4 as well as the improvement of exercise-induced glucose uptake by phosphatidylinositol 3-kinases (PI3K) / protein kinase B (Akt) and AMP-activated protein kinase (AMPK) signaling pathways in rodent skeletal muscle.The purpose of this paper is to clearly understand the mechanism underlying GLUT4 translocation and expression in rodent skeletal muscles. |
| Keywords: | Skeletal muscle Exercise Insulin resistance Glucose transporter 4 (GLUT4) Phosphatidylinositol 3-kinases (PI3K) Protein kinase B (Akt) AMP-activated protein kinase (AMPK) |
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