Mechanisms of muscle growth and atrophy in mammals and Drosophila |
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| Authors: | Rosanna Piccirillo Fabio Demontis Norbert Perrimon Alfred L. Goldberg |
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| Affiliation: | 1. Department of Cell Biology, Harvard Medical School, Boston, Massachusetts;2. Department of Oncology, IRCCS, Mario Negri Institute for Pharmacological Research, Milano, Italy;3. Department of Genetics, Harvard Medical School, Boston, Massachusetts;4. Department of Developmental Neurobiology, Division of Developmental Biology, St. Jude Children's Research Hospital, Memphis, Tennessee;5. Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts |
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| Abstract: | Background: The loss of skeletal muscle mass (atrophy) that accompanies disuse and systemic diseases is highly debilitating. Although the pathogenesis of this condition has been primarily studied in mammals, Drosophila is emerging as an attractive system to investigate some of the mechanisms involved in muscle growth and atrophy. Results: In this review, we highlight the outstanding unsolved questions that may benefit from a combination of studies in both flies and mammals. In particular, we discuss how different environmental stimuli and signaling pathways influence muscle mass and strength and how a variety of disease states can cause muscle wasting. Conclusions: Studies in Drosophila and mammals should help identify molecular targets for the treatment of muscle wasting in humans. Developmental Dynamics 243:201–215, 2014. © 2013 Wiley Periodicals, Inc. |
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| Keywords: | skeletal muscle growth muscle atrophy animal models of muscle wasting proteostasis |
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