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ENU‐3 functions in an UNC‐6/netrin dependent pathway parallel to UNC‐40/DCC/frazzled for outgrowth and guidance of the touch receptor neurons in C. elegans |
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| Authors: | Callista Yee Roxana Florica Jeffrey Fillingham Marie T Killeen | |
| Affiliation: | 1. Graduate Program in Molecular Science, Ryerson University, Toronto, Ontario, Canada M5B 2K3;2. Department of Chemistry and Biology, Ryerson University, Toronto, Ontario, Canada;3. Graduate Program in Biology, York University, Toronto, Ontario, Canada | |
| Abstract: | Results: An enu‐3 mutation enhances defects in ventral guidance of the processes of the AVM and PVM touch receptor neurons, the dorsal guidance of the distal tip cell and causes additional architectural defects in axons in unc‐40 mutant strains in an UNC‐6 dependent manner. These observations suggest that ENU‐3 and UNC‐40 function in parallel pathways dependent on UNC‐6. ENU‐3 depends on the presence of UNC‐40 for its full effect on motor neuron axon outgrowth. | |
| Keywords: | UNC‐6/Netrin UNC‐5 UNC‐40/DCC ENU‐3 AVM DA and DB motor neuron axon outgrowth | |
