| 童年期情绪性多食与多基因遗传风险对青春期发育的交互效应研究 |
| |
| 引用本文： | 刘婉旭,江伟康,赵莉,熊静远,苏普玉,万宇辉,方姣,成果,孙莹.童年期情绪性多食与多基因遗传风险对青春期发育的交互效应研究[J].中国学校卫生,2021,42(4):497-500. |
| |
| 作者姓名： | 刘婉旭 江伟康 赵莉 熊静远 苏普玉 万宇辉 方姣 成果 孙莹 |
| |
| 作者单位： | 1.安徽医科大学公共卫生学院，合肥，230032 |
| |
| 基金项目： | 国家自然科学基金项目81872638 |
| |
| 摘 要： | 目的 探讨童年期情绪性多食与多基因遗传风险对男女童青春期发育的交互效应，为进一步开展儿童青春期发育研究提供参考。 方法 通过整群抽样的方法，于2016年3月(T0)从安徽省蚌埠市2所小学招募896名一至三年级学生，建立青春期发育队列，之后2017—2019年每年开展1次随访调查(T1、T2、T3)。评估儿童情绪性多食与年度青春期发育状况(男童睾丸容积和女童乳房发育)，借助非线性生长模型拟合男女童的青春期发育时相与速度，基于17个与青春期发育提前相关的SNPs计算多基因遗传风险评分。采用分层线性回归分别检验情绪性多食与多基因遗传风险对男女童青春期发育的交互效应。 结果 896名儿童T1时情绪性多食行为报告率为22.7%。控制分娩方式、出生体重等协变量后，在青春期发育提前高遗传风险女童中，情绪性多食仅与青春期发育速度加快存在相关性(B=0.19，95%CI=0.07~0.32, P < 0.01)，与青春期发育时相无相关性(B=0.14，95%CI=- 0.12~0.41, P=0.28)。在低遗传风险女童以及不同遗传风险的男童中，情绪性多食与青春期发育时相和速度间差异无统计学意义(P值均>0.05)。 结论 青春期发育提前高遗传风险女童中情绪性多食与青春期发育速度加快有关。需要开展更多纵向研究检验多基因遗传风险与童年期饮食行为对男女童青春期发育的交互影响。
|
| 关 键 词： | 饮食习惯 基因 遗传 青春期 回归分析 儿童 |
| 收稿时间： | 2021-01-22 |
Interaction effects between childhood emotional overeating and polygenic influences on pubertal timing and tempo |
| |
| Affiliation: | 1.School of Public Health, Anhui Medical University, Hefei(230032), China |
| |
| Abstract: | Objective To explore the interaction effects and possible sex differences in childhood emotional overeating and polygenic influences on adolescent pubertal timing and tempo. Methods In March 2016 (T0), all participants were recruited from grades 1 to 3 from two primary school of Bengbu, Anhui Province using cluster sampling, and follow-up surveys were conducted once per year (T1, T2, T3). Emotional overeating was assessed at T1 and pubertal development was assessed annually (breast Tanner stage in girls and testicular volume in boys). The nonlinear growth model was used to estimate pubertal timing and tempo. Polygenic risk scores were calculated based on 17 SNPs for early pubertal timing. Hierarchical linear regression was performed to examine the interaction effects between childhood emotional overeating and polygenic risk scores on pubertal timing and tempo. Results The complete data of 896 children were analyzed, including 373 boys (41.60%) and 523 girls (58.40%). A total of 203 (22.7%) children reported emotional overeating behavior at T1. After adjusting for several variables including early life adversity, delivery mode, and birthweight, only emotional overeating was associated with accelerated pubertal tempo among girls with a high genetic risk (B=0.19, 95%CI=0.07~0.32, P < 0.01), although there was no association with pubertal timing (B=0.14, 95%CI=-0.12~0.41, P=0.28). In girls with a low genetic risk and boys, no evidence was found to support interaction effects between childhood emotional overeating and polygenic influences on pubertal timing and tempo (P > 0.05). Conclusion Emotional overeating was associated with a faster pubertal tempo in girls who had a high genetic risk of early pubertal development. |
| |
| Keywords: | |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《中国学校卫生》浏览原始摘要信息 |
|
点击此处可从《中国学校卫生》下载全文 |
|
