| 绝经激素治疗与女性恶性肿瘤 |
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| 引用本文： | 周文杰,吴洁.绝经激素治疗与女性恶性肿瘤[J].协和医学杂志,2021,12(2):157-162. |
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| 作者姓名： | 周文杰 吴洁 |
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| 作者单位： | 江苏省人民医院/南京医科大学第一附属医院妇产科，南京 210036 |
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| 基金项目： | 国家自然科学基金面上项目81771540江苏省妇幼保健重点学科FXK201701江苏省医学创新团队CXTDA2017004 |
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| 摘 要： | 医学的快速发展显著提高了恶性肿瘤患者的生存率和生存时间，因此，越来越多的女性恶性肿瘤幸存者将经历自然绝经或由于肿瘤治疗导致的早发性卵巢功能不全(premature ovarian insufficiency，POI)。自然绝经或POI带来的雌激素水平缺乏，可引起潮热、出汗、失眠、泌尿生殖道萎缩等一系列症状，远期负面影响包括心血管疾病、骨质疏松等风险增加，严重影响女性生活质量。因此，绝经激素治疗(menopausal hormone therapy，MHT)在女性恶性肿瘤幸存者中的应用日益受到关注。本文将对MHT与女性恶性肿瘤的关系及恶性肿瘤幸存者应用MHT的利弊进行分析。
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| 关 键 词： | 女性 恶性肿瘤 绝经激素治疗 获益 风险 |
| 收稿时间： | 2020-12-01 |
Menopausal Hormone Therapy and Female Cancer |
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| Affiliation: | Department of Obstetrics and Gynecology, the First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing 210036, China |
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| Abstract: | The rapid development of medicine has improved the survival rate and survival time of women with malignant tumors. More and more women with malignant tumors are experiencing either natural menopause or premature ovarian insufficiency (POI) due to the side effects of tumor therapy. Estrogen deficiency causes a series of perimenopausal symptoms such as hot flashes, sweating, insomnia, and urogenital tract atrophy, as well as long-term negative risks of cardiovascular disease and osteoporosis, which seriously affect women's quality of life. Therefore, the application of menopausal hormone therapy (MHT) in female malignant tumor survivors was increasingly concerned. Therefore, we evaluated the benefits and risks of MHT in female malignant tumor survivors in this review. |
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