| 扫描式葡萄糖监测系统中目标范围时间与糖化血红蛋白的相关性 |
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| 引用本文： | 邓明群,周丽媛,翟笑,刘洁颖,付俊玲,虞睿琪,潘妘頔,马丽媛,于淼,许建萍,李文慧,冯凯,肖新华. 扫描式葡萄糖监测系统中目标范围时间与糖化血红蛋白的相关性[J]. 协和医学杂志, 2021, 12(4): 526-530. DOI: 10.12290/xhyxzz.20200035 |
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| 作者姓名： | 邓明群 周丽媛 翟笑 刘洁颖 付俊玲 虞睿琪 潘妘頔 马丽媛 于淼 许建萍 李文慧 冯凯 肖新华 |
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| 作者单位： | 中国医学科学院 北京协和医学院 北京协和医院内分泌科 卫生健康委内分泌重点实验室，北京 100730 |
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| 基金项目： | 国家重点研发计划2017YFC1309603 |
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| 摘 要： | 目的 分析中国成人1型糖尿病(type 1 diabetes mellitus,T1DM)患者扫描式葡萄糖监测系统(flash glu-cose monitoring system,FGMS)衍生的目标范围时间(time in range,TIR)与糖化血红蛋白(glycated hemoglobin,HbA1c)的关...
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| 关 键 词： | 1型糖尿病 扫描式葡萄糖监测系统 目标范围时间 |
| 收稿时间： | 2020-02-17 |
Relationship between HbA1c and the Time in Range Derived from Flash Glucose Monitoring System |
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| Affiliation: | Department of Endocrinology, Key Laboratory of Endocrinology, National Health Commission of the People's Republic of China, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China |
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| Abstract: | Objective To explore the relationship between HbA1c and time in range (TIR) derived from flash glucose monitoring system (FGMS) in Chinese adults with type 1 diabetes mellitus (T1DM). Methods Adult T1DM patients attended the outpatient department of Peking Union Medical College Hospital (PUMCH) from October 2018 to March 2019 were included. HbA1c and data of FGMS were obtained at the same time. TIR was calculated, and the relationship between TIR and HbA1c was investigated by Spearman correlation and regression analysis. Results A total of 77 patients who met the inclusion and exclusion criteria were included in the analysis. The average HbA1c was (7.5±1.3)%; TIR was 62.0 (48.7, 67.8)% and coefficient of variation(CV) was (39.7±8.1)%. TIR derived from FGMS had a negative liner correlation with HbA1c (r=-0.645, P < 0.001). The regression equation is: HbA1c=10.58-0.05×TIR. The HbA1c level is decreased by 0.5% for every 10% increase in TIR. TIR was negatively correlated with HbA1c in patients with both stable glucose (CV < 36%) and unstable glucose (CV≥36%), but the correlation coefficient between TIR and HbA1c in patients with stable glucose was higher. For a specific TIR, HbA1c was higher in patients with stable glucose. Conclusion The FGMS-derived TIR could be helpful in the glucose management in Chinese adults with T1DM, and glucose variability should be taken into consideration while interpreting the relationship between TIR and HbA1c. |
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