| 2016年天津市健康人群脑膜炎奈瑟菌W135群、Y群抗体水平调查 |
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| 引用本文： | 骆晓艳,张维,陈伟,黄海涛,高志刚. 2016年天津市健康人群脑膜炎奈瑟菌W135群、Y群抗体水平调查[J]. 疾病监测, 2018, 33(7): 569-572. DOI: 10.3784/j.issn.1003-9961.2018.07.009 |
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| 作者姓名： | 骆晓艳 张维 陈伟 黄海涛 高志刚 |
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| 作者单位： | 天津市疾病预防控制中心，天津 300011 |
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| 摘 要： | ![]()
目的了解健康人群W135群、Y群脑膜炎奈瑟菌（Nm）的抗体水平，为科学防控流行性脑脊髓膜炎（流脑）提供依据。方法2016年在天津市市区、近郊和远郊的不同地理区域按年龄分层随机抽样，采集健康人群血清811份，用酶联免疫吸附试验检测Nm W135群、Y群IgG抗体水平。结果811名调查对象的Nm W135群和Y群的抗体阳性率分别为26.51%、29.96%，抗体浓度中位数均＜0.01 μg/ml。W135群抗体阳性率男性与女性分别为21.07%、31.20%，差异有统计学意义（χ2＝10.610，P＝0.001）。Y群抗体阳性率男性与女性分别为26.93%和32.57%，差异无统计学意义（χ2＝3.051，P＝0.081）。不同地区Nm W135群和Y群抗体阳性率的差异有统计学意义（χ2＝7.682，P＝0.001；χ2＝89.559，P＝0.001），市区最高（W135群抗体阳性率44.00%，Y群抗体阳性率49.50%）、其次是近郊（W135群抗体阳性率27.49%，Y群抗体阳性率31.87%）、最低的是远郊区（W135群抗体阳性率7.00%，Y群抗体阳性率6.50%）。不同年龄组Nm W135群和Y群抗体阳性率有统计学差异（χ2＝81.434，P＝0.001；χ2＝34.391，P＝0.001），均以50岁及以上年龄组人群最高（W135群抗体阳性率为52.50%，Y群抗体阳性率为40.00%）。结论天津市存在Nm W135、Y群感染，且人群易感性较高，应加强对流行性脑脊髓膜炎的监测，严防流脑W135、Y群暴发流行。
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| 关 键 词： | 流行性脑脊髓膜炎 W135群脑膜炎奈瑟菌 Y群脑膜炎奈瑟菌 抗体水平 |
| 收稿时间： | 2018-05-20 |
Investigation of antibody level against Neisseria meningitidis W135 and Y in healthy population in Tianjin, 2016 |
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| Affiliation: | Tianjin Municipal Center for Disease Control and Prevention, Tianjin 300011, China |
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| Abstract: | ![]()
ObjectiveTo understand the antibody level against Neisseria meningitidis W135 and Y in healthy population in Tianjin and provide scientific evidence for the prevention and control of meningococcal meningitis.MethodsIn 2016, a total of 811 healthy people were selected in urban, suburb and outer suburb areas in Tianjin through age-stratified random sampling. Blood samples were taken from them to detect IgG against N. meningitidis W135 and Y with enzyme-linked immunosorbent assay(ELISA).ResultsThe positive rate of antibody against N. meningitidis W135 and Y were 26.51% and 29.96% respectively, the median of antibody titers were all ＜0.01 μg/ml. The positive rate of IgG against N. meningitidis W135 was 21.07% in males and 31.20% in females, the difference was significant (χ2＝10.610, P＝0.001). The positive rate of IgG against N. meningitidis Y was 26.93% in males and 32.57% in females, the difference was not significant (χ2＝3.051, P＝0.081). The positive rates of IgG were highest in urban area (44.00% for W135 and 49.50% for Y), followed by those in suburb area (27.49% for W135, 31.87% for Y) and in outer suburb area (7.00% for W135, 6.50% for Y), the differences were significant (χ2＝7.682, P＝0.001; χ2＝89.559, P＝0.001). In different age group, the positive rates of IgG against W135 and Y were highest in age group ＞50 years (52.50% for W135, 40.00% for Y), the differences had significance (χ2＝81.434, P＝0.001; χ2＝34.391, P＝0.001).ConclusionInfections with N. meningitidis W135 and Y were detected in Tianjin, and general population is susceptible to the infection. It is necessary to strengthen the surveillance for meningococcal meningitis and take strict measures to prevent the outbreaks ofN. meningitidis W135 and Y. |
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