| 3D打印PEEK材料血管外支架建模及制作方法的可行性和有效性 |
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| 引用本文： | 郭奕彤,梁嘉赫,伊江浦,杨勇,张泽凯,陈云涛,张波,袁丽君,曹铁生.3D打印PEEK材料血管外支架建模及制作方法的可行性和有效性[J].心脏杂志,2019,31(6):689-693. |
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| 作者姓名： | 郭奕彤 梁嘉赫 伊江浦 杨勇 张泽凯 陈云涛 张波 袁丽君 曹铁生 |
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| 作者单位： | 1.3D打印研究中心 第四军医大学 |
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| 摘 要： | 目的 证明用于治疗胡桃夹综合征的3D打印聚醚醚酮（PEEK）材料血管外支架的三维建模和制作方法的可行性和有效性。 方法 以37例胡桃夹综合征患者为对象，利用患者的CT影像数据，分别对左肾静脉（LRV）受压迫处的动脉和静脉部分进行三维重建并进行3D打印。根据患者动静脉三维数字模型设计血管外支架，并利用PEEK材料进行3D打印。将3D打印PEEK材料血管外支架在1:1动静脉模型上模拟置入并进行术前规划。利用T检验对比分析患者术前和术后3个月的复查数据。 结果 术前CT影像上测得LRV狭窄处直径均值为（2.81 ± 1.67） mm，动静脉三维数字模型上测得其均值为（2.85 ± 1.59）mm，误差绝对值为（0.17 ± 0.21）mm。患者术前与术后3个月复查结果显示，LRV狭窄处直径（P < 0.01）、LRV肾门处直径与狭窄处比值（P < 0.01）以及LRV肾门处血流速度（P ＜ 0.05）均有显著性差异。37位患者术后均无并发症，其中有22位症状完全消失，15位症状明显缓解。CT影像显示支架位置稳定，无移位。 结论 用于治疗胡桃夹综合征的3D打印PEEK材料血管外支架的建模及制作程序可行且有效。
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| 关 键 词： | 胡桃夹综合征 三维建模 3D打印 聚醚醚酮 血管外支架 |
| 收稿时间： | 2019-10-27 |
Feasibility and effectiveness of modeling and manufacturing of 3D printed polyether ether ketone extravascular stent |
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| Affiliation: | 1.3D Printing Research Center2.Department of Ultrasound Diagnosis, Tangdu Hospital3.Department of Urology, Tangdu Hospital, Fourth Military Medical University, Xi’an 710038, Shaanxi, China |
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| Abstract: | AIM To demonstrate the feasibility and effectiveness of modeling and 3D printing of polyether ether ketone (PEEK) extravascular stent for the treatment of nutcracker syndrome. METHODS Firstly, the arteries and the left renal vein (LRV) were reconstructed and 3D printed based on the patient’s computational tomography (CT) imaging data. Secondly, the extravascular stent was carefully designed according to the three-dimensional digital models of arteries and veins. Afterwards, the stent was 3D printed using PEEK material. Finally, the 3D printed PEEK external vascular stent was placed on the 1:1 arteriovenous model in order to do preoperative planning. The t test was adopted to compare and analyze the pre- and postoperative examination data of patients. RESULTS The mean diameter of LRV at the stenotic area measured on the preoperative CT image was (2.81 ± 1.67) mm and that measured on the 3D digital model was (2.85 ± 1.59) mm, which gave the absolute value of error as (0.17 ± 0.21) mm. From the clinical perspective, the examination outcomes revealed that there were significant differences between pre- and postoperative results in the diameter of LRV at stenotic area (P＜0.01), the ratio of diameter of LRV at the hilum area to the stenosis (P< 0.01) and the blood flow velocity at LRV hilum (P< 0.05). In addition, of the 37 patients, 22 had symptoms completely resolved after surgery, 15 had obvious relief, and no patients had any complications. CT images showed the stent was stable and there was no displacement. CONCLUSION The process of Modeling and 3D printing of the PEEK extravascular stent for the treatment of nutcracker syndrome is feasible and effective. |
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