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| 口腔鳞癌浸润方式与颈淋巴结转移关系的组织学研究 | |
| 引用本文： | 杨湛,普苹,温玉明,付红梅,李继梅. 口腔鳞癌浸润方式与颈淋巴结转移关系的组织学研究[J]. 华西口腔医学杂志, 2005, 23(1): 49-52 |
| 作者姓名： | 杨湛 普苹 温玉明 付红梅 李继梅 |
| 作者单位： | 1.昆明医学院第一附属医院 口腔颌面外科;2.昆明医学院第一附属医院 病理科; 3.四川大学华西口腔医院 口腔颌面外科,四川 成都610041; 4.昆明医学院第一附属医院 临床研究中心,云南 昆明650032 |
| 基金项目： | 云南省自然科学基金资助项目(96C137Q和2000C0012R) |
| 摘 要： | 目的 探讨口腔鳞癌不同浸润方式和颈淋巴结转移的关系。方法 利用Yamamoto的浸润方式分型法,对 200例临床和病理资料完整的口腔鳞癌患者进行组织学回顾性研究和分析。结果 鳞癌的浸润方式与鳞癌的颈淋巴结转移明显相关(P<0·001)。Ⅰ型~Ⅳd型浸润方式相对应的颈淋巴结转移率分别为0、5·9%、14·3%、63·0% 和82·9%。在80例Ⅲ~Ⅳd型浸润方式的转移患者中,Ⅳd型浸润方式常伴随N2期转移(P<0·05),而Ⅲ型和Ⅳc 型浸润方式则更常伴有N1期转移(P<0·05)。Ⅳc型浸润有41·2%的Ⅰ级平面和79·4%的Ⅰ~Ⅱ级平面转移机率,而Ⅳd型浸润的转移平面较为弥散,两者间有显著性差异(P<0·05)。结论 不同的口腔鳞癌浸润方式有着截然不同的颈淋巴结转移机率、转移分期和转移平面。对口腔鳞癌原发灶肿瘤-宿主边缘浸润方式的分型研究,有助于判断口腔鳞癌的区域性淋巴结转移情况,提供临床治疗方案设计和预后预测的依据。 |
| 关 键 词： | 口腔鳞癌 淋巴结转移 浸润方式 |
| 文章编号： | 1000-1182(2005)01-0049-04 |
| 收稿时间： | 2005-02-25 |
| 修稿时间： | 2003-12-24 |
The Histological Research between the Mode of Invasion and Cervical Lymph Node Metastasis in Squamous Cell Carcinoma of the Oral Cavity |
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| YANG Zhan,Pu Ping,WEN Yu-ming,FU Hong-mei,LI Ji-mei. The Histological Research between the Mode of Invasion and Cervical Lymph Node Metastasis in Squamous Cell Carcinoma of the Oral Cavity[J]. West China journal of stomatology, 2005, 23(1): 49-52 | |
| Authors: | YANG Zhan Pu Ping WEN Yu-ming FU Hong-mei LI Ji-mei |
| Affiliation: | 1.Dept.ofOral andMaxil- lofacial Surgery,The FirstAffiliatedHospital ofKunmingMedical College,Kunming650032,China; 2.Dept.ofPathology,The First AffiliatedHospital ofKunmingMedical College,Kunming650032,China; 3.Dept.ofOral andMaxillofacialSurgery,West China College ofStomatology,Sichuan University,Chengdu610041,China; 4.Clinical Research Center,The First Affiliated Hospital ofKunmingMedical College,Kunming650032,China |
| Abstract: | OBJECTIVE: The relationship between the mode of tumor invasion in the tumor-host borderline and the frequency of cervical lymph node metastasis was investigated in squamous cell carcinoma of the oral cavity. METHODS: 200 cases with histologically proven squamous cell carcinoma of the oral cavity were studied by histological method with HE stained. The mode of invasion in the tumor-host relationship was classified into five grades by Yamamoto's criteria. RESULTS: With regard to the relationship between the mode of invasion and metastasis, the more invasive the tumor tissue was, the more frequent the metastasis formed (P < 0.001). The frequency of metastasis in grades 1 and 2 was low (0 and 5.9%, respectively), The frequency of metastasis in grades 3 was moderate (14.3%), and that in grades 4c and 4d was highly rapid (63.0% and 82.9%, respectively). Single node metastases were frequent in grade 3 and grade 4c (66.7% and 58.8%, respectively), while plural node metastases were frequent in grade 4d (70.6%, P < 0.05). Moreover, the distribution of metastasized lymph nodes was focused on level 1 (41.2%) or level 1 and 2 (79.4%) in grade 4c and was dispersed from level 1 to 4 in grade 4d (P < 0.05). In the present study, the degree of differentiation did not correlate well with the frequency of metastasis. CONCLUSION: These results indicate that the more invasive the tumor cells were to the host, the more frequent the metastasis formed. The different mode of invasion would accompany with different frequency of metastasis, different number and distribution of metastasized lymph nodes. |
| Keywords: | oral squamous cell carcinoma lymph node metastases the mode of invasion |
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