| 耳穴综合疗法用于体外受精-胚胎移植经阴道穿刺取卵术的临床观察 |
| |
| 引用本文： | 王美霞,滕依丽.耳穴综合疗法用于体外受精-胚胎移植经阴道穿刺取卵术的临床观察[J].中华全科医学,2018,16(11):1864-1867. |
| |
| 作者姓名： | 王美霞 滕依丽 |
| |
| 作者单位： | 1. 温州市中西医结合医院中医妇科, 浙江 温州 325000; |
| |
| 基金项目： | 浙江省温州市科技局2014年第二期科技计划项目(Y20140228) |
| |
| 摘 要： | 目的 评价耳穴综合疗法在辅助生殖技术(assisted reproductive technology,ART)取卵术中及术后的镇痛效应、不良反应发生率及其对炎性因子的影响。 方法 选择2013年1月-2014年12月在温州医科大学附属第一医院生殖中心施体外受精-胚胎移植(IVF-ET)术患者78例,随机分为治疗组和对照组,各39例,对照组给予丙泊酚麻醉,治疗组在对照组基础上给予耳穴综合疗法,比较2组患者的取卵时间、苏醒时间、术后疼痛评分及丙泊酚用量、实验室获卵率、受精率、卵裂率、临床妊娠率、流产率等指标,和白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)的表达水平及不良反应发生情况。 结果 治疗组取卵时间与对照组相比,差异无统计学意义(P>0.05);治疗组苏醒时间、丙泊酚用量及术后疼痛评分均显著优于对照组(P<0.05)。2组实验室获卵率、受精率、卵裂率、临床妊娠率及流产率差异均无统计学意义(P>0.05)。治疗前,2组IL-6、IL-8及TNF-α水平差异均无统计学意义(P>0.05);治疗后,2组IL-6、IL-8及TNF-α水平均明显高于治疗前,但治疗组治疗后明显低于对照组,差异具有统计学意义(P<0.05)。治疗组体动反应发生率显著低于对照组,差异具有统计学意义(P<0.05)。2组眩晕、呼吸抑制及恶心呕吐的发生率差异无统计学意义(P>0.05)。 结论 耳穴综合疗法辅助麻醉有助于降低西药的用量,增强镇痛效果,减少患者并发症的发生,降低恶心、呕吐等不良反应的发生,减少炎性因子表达,降低手术应激反应,值得临床推广。
|
| 关 键 词： | 耳穴综合疗法 体外受精-胚胎移植 辅助生殖技术 穿刺取卵 |
| 收稿时间： | 2018-04-20 |
Clinical observation of auricular point combined therapy in patients with transvaginal oocyte retrieval for in vitro fertilization-embryo transfer |
| |
| Affiliation: | Department of TCM Gynecology, Wenzhou Hospital of Integrated Chinese and Western Medicine, Wenzhou, Zhejiang 325000, China |
| |
| Abstract: | Objective To evaluate the analgesic effect, the incidence of adverse reactions and the influence on the inflammatory factors of the auricular point combined therapy in patients with transvaginal oocyte retrieval for in vitro fertilization-embryo transfer (IVF-ET). Methods Total 78 cases of IVF-ET in Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine from January, 2013 to December, 2014 were selected, and were randomly divided into treatment group and control group. The control group was given propofol anesthesia, while the treatment group received additional ear acupuncture therapy. The ovulation time, recovery time, postoperative pain score and propofol dosage, laboratory egg rate, fertilization rate, cleavage rate, clinical pregnancy rate, interleukin-8 (IL-8) and tumor necrosis factor-α (TNF-α), and the incidence of adverse events were analyzed and evaluated. Results There was no significant difference in the ovulation time between the two groups (P>0.05). The recovery time, propofol dosage and postoperative pain score in the treatment group were superior to the control group (P<0.05). There was no significant difference in egg rate, fertilization rate, cleavage rate, clinical pregnancy rate and abortion rate between the two groups (P>0.05). There was no significant difference in IL-6, IL-8 and TNF-α level between the two groups before the treatment (P>0.05). After the treatment, the levels of IL-6, IL-8 and TNF increased obviously in both groups, but those levels in the treatment group was significantly lower than those in the control group, the difference was statistically significant (P<0.05). The incidence of body movement was significantly lower in the treatment group than in the control group (P<0.05). There was no significant difference in the incidence of vertigo, respiratory depression and nausea and vomiting between the two groups (P>0.05). Conclusion Auricular acupuncture combined with anesthesia can reduce the dosage of western medicine, enhance the analgesic effect, reduce the incidence of complications, reduce the incidence of adverse reactions such as nausea and vomiting, reduce the expression of inflammatory factors, reduce the stress response. |
| |
| Keywords: | |
|
| 点击此处可从《中华全科医学》浏览原始摘要信息 |
|
点击此处可从《中华全科医学》下载全文 |
|
