| 德宏州HIV单阳夫妻双方丙型肝炎病毒感染状况及影响因素 |
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| 引用本文： | 王继宝,徐晴晴,王译葵,段星,杨锦,曹艳芬,杨涛,叶润华,杨跃诚,姚仕堂,丁盈盈,何纳,段松.德宏州HIV单阳夫妻双方丙型肝炎病毒感染状况及影响因素[J].中华疾病控制杂志,2018,22(12):1283-1286. |
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| 作者姓名： | 王继宝 徐晴晴 王译葵 段星 杨锦 曹艳芬 杨涛 叶润华 杨跃诚 姚仕堂 丁盈盈 何纳 段松 |
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| 作者单位： | 1. 德宏州疾病预防控制中心艾滋病性病防制科, 云南 德宏州 678400; |
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| 基金项目： | 国家重点地区艾滋病防治项目国家科技重大专项（2013zx10004-906） |
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| 摘 要： | 目的 了解云南省德宏州人类免疫缺陷病毒（human immunodeficiency virus，HIV）单阳夫妻双方（HIV感染者及其阴性配偶）丙型肝炎病毒（viral hepatitis C，HCV）感染情况及其影响因素。方法 收集HIV单阳夫妻的人口学特征、行为学指标和血样，并进行HCV抗体检测，应用χ2检验和Logistic回归分析不同因素对HCV感染率的影响。结果 582对HIV单阳家庭中，夫妻双方均感染HCV有12对（2.1%），仅一方感染HCV有138对（23.7%）。HIV阳性配偶HCV感染率为23.2%，HIV阴性配偶HCV感染率为4.6%，差异有统计学意义（χ2=83.641，P<0.001）。男性配偶中，HIV阳性者HCV感染率为32.6%，HIV阴性者HCV感染率为4.6%，差异有统计学意义（χ2=56.828，P<0.001）；女性配偶中，HIV阳性者HCV感染率为4.6%，HIV阴性者HCV感染率为4.7%，二者无统计学差异（χ2<0.001，P=0.958）。多因素Logistic回归分析显示，男性配偶中35~46岁、景颇族、HIV阳性、吸毒是HCV感染的危险因素。结论 德宏州HIV单阳夫妻特别是HIV阳性男性配偶中HCV感染率高，HCV存在性传播的潜在威胁，有必要加强对HIV单阳家庭的丙型肝炎防治，对男性和女性配偶采取针对性的预防干预措施。
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| 关 键 词： | HIV HCV 单阳家庭 影响因素 |
| 收稿时间： | 2018-07-05 |
Prevalence and correlates of HCV infection among HIV serodisordant couples in Dehong prefecture of Yunnan province |
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| Affiliation: | 1. Department of STD and AIDS Prevention and Control, Dehong Prefecture Center for Disease Control and Prevention, Dehong prefecture 678400, China;2. National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China;3. Department of Epidemiology, School of Public Health, Fudan University, Shanghai 200032, China |
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| Abstract: | Objective To examine the prevalence and correlates of HCV infection among HIV serodisordant couples in Dehong prefecture, Yunnan province. Methods A cross-sectional questionnaire interview was administered to solicit sociodemographic and behavioral characteristics of HIV serodiscordant couples. Blood was collected for HCV antibody testing using commercial Anti-HCV EIA Kit. Results Among 582 HIV serodiscordant couples, 12 (2.1%) couples were concordantly HCV positive, and 138 (23.7%) were HCV-discordant. The HCV prevalence was 23.2% for HIV-positive spouses, significantly higher than that (4.6%) for HIV-negative spouses (χ2=83.641, P<0.001). The HCV prevalence was 32.6% for HIV-positive male spouses, significantly higher than that (4.6%) for HIV-negative male spouses (χ2=56.828, P<0.001). No significant difference in HCV prevalence was found between HIV-positive (4.6%) and HIV-negative female spouses (4.7%) (χ2<0.001, P=0.958). Multivariable Logistic regression analysis indicated that HCV infection was positively associated with age at 35-46, Jingpo minority, HIV infection and drug use. Conclusions HCV prevalence was high among HIV-serodiscordant couples especially HIV-infected male spouses. There was a potential sexual transmission of HCV. These findings underscore the importance of enhancing tailored HCV prevention and control among these people. |
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