| 慢盆消炎方联合甲硝唑和左氧氟沙星治疗子宫内膜炎的临床观察 |
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| 引用本文： | 赵小迎,蔡平生.慢盆消炎方联合甲硝唑和左氧氟沙星治疗子宫内膜炎的临床观察[J].中华全科医学,2018,16(11):1860-1863. |
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| 作者姓名： | 赵小迎 蔡平生 |
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| 作者单位： | 温州市中西医结合医院妇产科, 浙江 温州 325000 |
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| 基金项目： | 浙江省2013年度省级公益性技术应用研究计划(2013C33098) |
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| 摘 要： | 目的 观察慢盆消炎方联合甲硝唑和左氧氟沙星治疗子宫内膜炎的临床疗效。 方法 以2015年6月-2016年12月于温州市中西医结合医院妇产科就诊的190例子宫内膜炎患者为研究对象,随机数字表法分为研究组(95例)和对照组(95例),对照组患者予以甲硝唑和左氧氟沙星静脉治疗,研究组患者在此基础上,增加慢盆消炎方内服,观察患者治疗期间药物不良反应,记录患者症状消失时间,评价疗效水平,统计1年内炎症复发情况。 结果 研究组患者治疗后血清MMP-9和IL-4显著低于对照组,而IL-2和IL-10显著高于对照组(P<0.05);研究组患者盆腔区域疼痛和炎性分泌物增多症状消失时间(9.31±2.63)d和(13.72±3.27)d]均显著短于对照患者(14.28±3.51)d和(20.43±4.16)d],P<0.05;研究组患者子宫内膜炎总体有效率(94.74%)显著高于对照组(85.26%,χ2=4.737,P=0.030)。治疗后1年内,研究组患者子宫内膜炎复发率(11.58%)显著低于对照组(24.21%,χ2=5.158,P=0.023)。治疗期间,研究组患者药物不良反应总体发生率(10.53%)与对照组患者(7.37%)比较差异无统计学意义(χ2=0.581,P=0.446)。 结论 较单纯西医治疗,慢盆消炎方联合甲硝唑和左氧氟沙星治疗,可显著抑制子宫内膜炎症反应,缩短康复周期,提高疗效水平,预防炎症复发,且不增加药物不良反应。
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| 关 键 词： | 慢盆消炎方 甲硝唑 左氧氟沙星 子宫内膜炎 中西医结合治疗 |
| 收稿时间： | 2018-05-16 |
Observation on the clinical effect of Manpenxiaoyan decoction combined with metronidazole and levofloxacin in the treatment of endometritis |
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| Affiliation: | Department of Obstetrics and Gynecology, Integrated Traditional Chinese and Western Medicine Hospital of Wenzhou, Wenzhou, Zhejiang 325000, China |
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| Abstract: | Objective To observe the clinical effect of Manpenxiaoyan decoction combined with metronidazole and levofloxacin in the treatment of endometritis, and effect on the level of inflammatory factors in patients. Methods Total 190 cases of endometritis patients were studied, and all the patients were randomly divided into the study group (95 cases) and the control group (95 cases). The patients in the control group were treated with metronidazole and levofloxacin intravenously, and the patients in the study group were increased the Manpenxiaoyan decoction on the basis of the control group. The adverse reactions during treatment were observed, the time of symptom disappearance was recorded, the curative effect level was evaluated, and the recurrence of inflammation within 1 years was counted. Results The serum MMP-9 and IL-4 levels of the study group were significantly lower than those of the control group after treatment, while IL-2 and IL-10 levels were significantly higher than those of the control group (P<0.05). The time of pelvic area pain and leucorrhea disappeared in the study group(9.31±2.63)d and (13.72±3.27)d] were significantly shorter than those in the control group(14.28±3.51) d and (20.43±4.16)d], P<0.05. The total effective rate of the treatment of patients with endometritis in the study group (94.74%) was significantly higher than that of the control group (85.26%, χ2=4.737, P=0.030). Within 1 years after treatment, the recurrence rate of endometritis in the study group (11.58%) was not significantly different from that in the control group (24.21%, χ2=5.158, P=0.023). During the treatment, the overall incidence of adverse drug reactions (10.53%) in the study group was not significantly different from that in the control group (7.37%, χ2=0.581, P=0.446). Conclusion Compared with simple western medicine, Manpenxiaoyan decoction combined with metronidazole and levofloxacin can significantly inhibit the inflammation of the endometrium, shorten the recovery cycle, improve the level of curative effect, prevent the recurrence of the inflammation, and do not increase the adverse drug reaction. |
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