| 神经节苷脂联合鼠神经生长因子治疗急性脑出血的临床研究 |
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| 引用本文： | 邵传锋,陈佩雷,吴赛珍,陈朴.神经节苷脂联合鼠神经生长因子治疗急性脑出血的临床研究[J].中华全科医学,2018,16(10):1646-1649. |
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| 作者姓名： | 邵传锋 陈佩雷 吴赛珍 陈朴 |
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| 作者单位： | 1. 乐清市人民医院临床药学室, 浙江 乐清 325600; |
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| 基金项目： | 国家卫生计生委医药卫生科技发展研究中心重大疾病防治科技行动计划(ZX-01-C2016030) |
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| 摘 要： | 目的 探讨神经节苷脂联合鼠神经生长因子应用于急性出血患者治疗中的疗效及经济效益。 方法 分析乐清市人民医院2015年6月-2017年6月脑外科和神经内科收治的急性脑出血患者240例,根据治疗药物的不同将患者分为观察组(应用神经节苷脂联合鼠神经生长因子)68例和对照组(单独应用鼠神经生长因子)72例,比较2组临床疗效、生活质量和药物花费。 结果 观察组患者治疗后2周的病情有效率高于对照组,差异有统计学意义(χ2=4.148,P=0.042);观察组和对照组治疗2周后患者颅内出血体积均减少,但观察组减少程度较对照组大,差异有统计学意义(t=13.000,P<0.01);观察组和对照组治疗2周后患者血肿周围水肿面积均减少,但观察组减少程度较对照组大,差异有统计学意义(t=7.856,P<0.001);治疗前2组外周血IL-6水平比较差异无统计学意义(t=0.178,P=0.867),治疗2周后,2组患者IL-6水平均降低,观察组降低较明显,差异有统计学意义(t=7.170,P<0.001);治疗前2组ADL评分比较差异无统计学意义(P>0.05),治疗3个月后,观察组ADL评分较对照组显著升高,差异有统计学意义(P<0.05);观察组住院天数较对照组低,差异有统计学意义(13.9±4.2)d vs. (25.8±6.4)d,t=17.030,P<0.001)。2组在药物花费数额差异无统计学意义(5 764.3±1 002.9)元 vs. (5 499.7±998.5)元,t=1.875,P=0.062]。 结论 神经节苷脂和鼠神经生长因子联合用药治疗急性脑出血能显著改善患者病情及生活质量,且不显著增加患者经济负担,值得在临床中推广应用。
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| 关 键 词： | 急性脑出血 神经节苷脂 鼠神经生长因子 疗效 费用分配 |
| 收稿时间： | 2017-11-20 |
Clinical research of efficacy of ganglioside combined with nerve growth factor for acute cerebral hemorrhage |
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| Affiliation: | Department of Pharmacy, Yueqing People's Hospital, Yueqing, Zhejiang 325600, China |
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| Abstract: | Objective To investigate the efficacy and economic benefits of ganglioside combined with murine nerve growth factor in the treatment of patients with acute cerebral hemorrhage. Methods A total of 240 patients with acute cerebral hemorrhage admitted from June, 2015 to June, 2017 in our department were divided into observation group (ganglioside combined with mouse nerve growth factor) and control group (mouse nerve growth factor alone). The effective rate of clinical efficacy, quality of life and drug cost were compared between the two groups. Results The effective rate of patients in the observation group was higher than that of control group two weeks after the treatment (χ2=4.148, P=0.042). The volume of intracranial hemorrhage in the observation group and control group decreased after 2 weeks of treatment, but the reduction in the observation group was larger than that in the control group (t=13.000, P<0.001). After 2 weeks of treatment, the edema area around the hematoma of the observation group and the control group decreased, but the reduction in the observation group was larger than that of the control group (t=7.856, P<0.001). There was no significant difference in IL-6 level between the two groups before the treatment (t=0.178, P=0.867). After 2 weeks of treatment, the levels of IL-6 in both groups decreased and the decrease in the observation group was statistically significant significance of learning (t=7.170, P<0.001); There was no significant difference in ADL score between the two groups before the treatment (P>0.05). After 3 months of treatment, the ADL score of the observation group was significantly higher than that of the control group (P<0.05). The days of hospitalization in the observation group were lower than those in the control group, with significant difference(13.9±4.2) d vs. (25.8±6.4) days, t=17.030, P<0.01). There was no significant difference in medication spending between the two groups (5 764.3±1 002.9) vs (5 499.7±998.5), t=1.875, P=0.062]. Conclusion The combination of ganglioside and murine nerve growth factor in the treatment of acute intracerebral hemorrhage can significantly improve the patient's condition and quality of life, and does not significantly increase the economic burden on patients, it is worth in the clinical application. |
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