| 不同代谢肥胖表型与颈动脉内膜中层厚度的相关性研究 |
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| 引用本文： | 黄超,曹亚英,田耀华,宋菁,杨燕芬,项骁,孙可欣,杨超,黄少平,刘晓芬,秦雪英,唐迅,李劲,高培,吴涛,陈大方,胡永华.不同代谢肥胖表型与颈动脉内膜中层厚度的相关性研究[J].中华疾病控制杂志,2018,22(1):4. |
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| 作者姓名： | 黄超 曹亚英 田耀华 宋菁 杨燕芬 项骁 孙可欣 杨超 黄少平 刘晓芬 秦雪英 唐迅 李劲 高培 吴涛 陈大方 胡永华 |
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| 作者单位： | 1. 北京大学公共卫生学院流行病与卫生统计学系, 北京 100191; |
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| 基金项目： | 国家自然科学基金（81230066，81473043） |
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| 摘 要： | 目的 探讨不同代谢肥胖表型与颈动脉内膜中层厚度（carotid intima-media thickness，CIMT）的关系。方法 对北京市社区居民进行一般人口学调查，血糖、血脂等检测，CIMT测量及身高、体重等体格检查。根据代谢正常或异常及体质指数（body mass index，BMI）正常或肥胖组合形成的四种代谢肥胖表型将研究对象分组，分析其与CIMT的相关性。结果 共纳入1 648名研究对象，平均年龄为（55.4±11.0）岁，男性占45.8%。多因素Logistic回归显示，在调整了年龄、性别、教育程度、吸烟、饮酒、活动情况、糖尿病家族史、低密度脂蛋白胆固醇（low-density lipoprotein cholesterol，LDL-C）后，与代谢正常体重正常组相比，代谢异常体重正常（OR=1.61，95%CI:1.01~2.56，P=0.046）和代谢异常肥胖组（OR=2.10，95%CI:1.32~3.32，P=0.002）CIMT增厚的风险较大。结论 代谢异常体重正常表型和代谢异常肥胖表型可能是CIMT增厚的危险因素，而代谢正常肥胖表型的CIMT增厚风险无差异，提示代谢异常相较肥胖可能对动脉粥样硬化风险影响更大。
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| 关 键 词： | 代谢 肥胖症 动脉粥样硬化 危险因素 |
| 收稿时间： | 2017-06-27 |
Association of carotid intima-media thickness and metabolic health and obesity status |
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| Affiliation: | 1. Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China;2. Renal Division, Peking University First Hospital;Peking University Institute of Nephrology, Beijing 100034, China;3. General Office, Fangshan District Center for Disease Control and Prevention, Beijing 102401, China;4. Department of Chronic Disease Control and Prevention, Fangshan District Center for Disease Control and Prevention, Beijing 102401, China |
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| Abstract: | Objective To explore the relationship between carotid intima-media thickness (CIMT) and metabolic health and obesity status. Methods A community-based study was conducted in rural communities in Beijing. Biochemical test, CIMT measurement, physical examination and questionnaire investigation were performed. Participants were divided into four groups according to their metabolic status and body mass index (BMI) to analyze the relationship between CIMT and metabolic health and obesity status. Results A total of 1 648 participants were recruited. The average age was (55.4±11.0) years old and men accounted for 45.8%. Logistic regression analysis showed that after adjusting for age, gender, smoke, drink, education, physical activity, diabetes family history and low-density lipoprotein cholesterol (LDL-C), the CIMT thickening rate were higher in metabolically unhealthy normal weight group (OR=1.61, 95% CI:1.01-2.56, P=0.046) and metabolically unhealthy obesity group (OR=2.10, 95% CI:1.32-3.32, P=0.002) than that in metabolically healthy normal weight group. Conclusion Metabolically unhealthy normal weight and metabolically unhealthy obesity might be risk factors for CIMT thickening, indicating that metabolically unhealthy status might have more influence on the development of atherosclerosis than obesity. |
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