| Beclin1和p62在结肠癌组织中的表达及临床意义 |
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| 引用本文： | 赵坚培,戴晓宇,谢阳阳.Beclin1和p62在结肠癌组织中的表达及临床意义[J].中华全科医学,2017,15(5):773. |
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| 作者姓名： | 赵坚培 戴晓宇 谢阳阳 |
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| 作者单位： | 宁波市第二医院肛肠外科, 浙江 宁波 315000 |
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| 摘 要： | 目的 探讨Beclin1和p62在结肠癌组织中和正常结肠黏膜的表达差异以及临床意义。 方法 采用免疫组织化学法对42例结肠患者癌组织以及正常黏膜组织中Beclin1以及p62的阳性表达率进行检测。比较不同病理资料中Beclin1以及p62的表达差异,并随访5年生存率,Cox回归分析影响结肠癌患者死亡的危险因素。运用SPSS 20.0统计软件进行统计学分析,P<0.05为差异有统计学意义。 结果 Beclin1在正常肠黏膜中表达阳性率高于癌组织,另外在T1~T2期中的阳性表达率高于T3~T4期的阳性率,以上差异有统计学意义(P<0.05)。p62蛋白在癌组织中表达升高,在正常组织中表达降低,2组间差异有统计学意义(P<0.05)。Cox回归分析显示,对于结肠癌的患者,p62是患者死亡的危险因素,联合使用p62以及Beclin1是预测结肠癌预后的良好指标。 结论 结肠癌患者的自噬活性降低,Beclin1与CEA的表达水平以及肿瘤的浸润深度有关,联合应用Beclin1以及p62可以较好地预测结肠癌患者的预后。
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| 关 键 词： | Beclin1 p62 结肠肿瘤 |
| 收稿时间： | 2016-10-01 |
The expression and clinical significance of Beclin1 and p62 in colon cancer tissue |
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| Affiliation: | Department of Anus and Intestine Surgery, the Second Hospital of Ningbo, Ningbo, Zhejiang 315000, China |
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| Abstract: | Objective To evaluate the expression and clinical significance of Beclin1 and p62 in colon cancer tissue. Methods Forty two patients with colon cancer were selected for this study.All the included patients are collected the cancer tissue and the normal colon tissue.Immunohistochemical staining was performed to test the expression of Beclin1 and p62.Five-year survival rate was recorded and the Cox regression analysis was conducted to analyses the risk factor for cancer death. Results The expression of Beclin1 is higher in the patients that CEA ≥ 5 ng/ml,normal tissue and the T1-T2 phase than that in CEA<5 ng/ml,cancer tissue and T3-T4 phase.The difference was significant difference (P<0.05).And the p62 expression is higher in the cancer tissue than that of normal tissue,and the difference was statistically significant (P<0.05).The Cox regression analysis indicated that the p62 is the risk factor for cancer death,and combined administration p62 with Beclin1 is the predicable factor for the cancer patient survival.SPSS 20.0 was used for statistically analyses and P<0.05 was considered as statistically significant. Conclusion The autophagy activity in colon cancer is decreased and the Beclin1 was correlated with the CEA level and depth of tumor invasion.Combined Beclin1 with p62 can be better predicting the colon cancer prognosis. |
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