| 血清铜、铁、锌与阿尔茨海默病性痴呆患者痴呆程度的关系探讨 |
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| 引用本文： | 江红霞,林勇,费玉娥,汤晨东,濮正平,昌盛.血清铜、铁、锌与阿尔茨海默病性痴呆患者痴呆程度的关系探讨[J].中华全科医学,2017,15(5):827. |
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| 作者姓名： | 江红霞 林勇 费玉娥 汤晨东 濮正平 昌盛 |
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| 作者单位： | 嘉兴市康慈医院老年科, 浙江 桐乡 314500 |
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| 基金项目： | 浙江省精神障碍诊疗和防治技术重点实验室开放课题项目(2015JSK04)浙江省嘉兴市科技计划项目(2014AY21066) |
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| 摘 要： | 目的 探讨阿尔茨海默病性痴呆(Alzheimer's disease,AD)患者血清铜、铁、锌与其痴呆程度的关系。 方法 纳入125例AD患者及40例健康对照者,AD患者根据简明心理状况测验(mini-mental state examination,MMSE)评分分为轻度痴呆组(21~26分)、中度痴呆组(10~20分)及重度痴呆组(<10分),所有受试者均测定血清铜、铁、锌含量。 结果 与对照组及轻度痴呆组比较,中度和重度痴呆组血清铜含量的差异具有统计学意义,提示与对照组及轻度痴呆组比较,中度和重度痴呆组患者体内血清铜含量增加。与对照组比较,轻度、中度和重度痴呆组血清铁含量的差异具有统计学意义,提示与对照组比较,AD患者体内血清铁含量减少。与对照组比较,轻度、中度和重度痴呆组血清锌含量的差异具有统计学意义,提示与对照组比较,AD患者体内血清锌含量减少。相关分析提示AD患者MMSE评分与血清铜含量呈负相关,与血清锌含量呈正相关,而与血清铁含量无相关性,说明痴呆程度越重,血清铜含量越高,血清锌含量越低。 结论 AD患者体内存在着微量元素的稳态失衡,AD患者血清中有些微量元素如铜、锌等的水平与AD的痴呆程度有一定的相关性。
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| 关 键 词： | 阿尔茨海默病性痴呆 痴呆程度 微量元素 铜 铁 锌 |
| 收稿时间： | 2016-04-12 |
Correlation between the severity of Alzheimer's disease and the levels of serum copper,iron and zinc |
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| Affiliation: | Department of Geriatrics, Kangci Hospital of Jiaxing, Tongxiang, Zhejiang 314500, China |
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| Abstract: | Objective To explore the correlation between the severity of Alzheimer's disease (AD) and the levels of serum copper,iron and zinc. Methods Total 165 subjects were selected and divided into the healthy group,and mild,moderate and sever dementia group according to the scores of Mini-Mental State Examination (MMSE),which defined scores of 21 to 26 as mild dementia,10 to 20 as moderate dementia,0 to 10 as sever dementia.The levels of serum copper,iron and zinc of all the subjects were tested. Results The levels of serum copper of the moderate and sever groups were statistically higher than those of the healthy group and mild group,while the levels of serum iron and zinc of all dementia groups were statistically lower than those of the healthy group which suggested there's a decrease of serum iron and zinc in AD patients.There's negative correlation between the scores of MMSE and the levels of serum copper;there's positive correlation between the scores of MMSE and the levels of serum zinc;while there's no correlation between the scores of MMSE and the levels of serum iron,which suggested the more sever the dementia was,the higher the serum copper was and the lower the serum zinc was. Conclusion There is imbalance of microelements in AD patient whose levels of serum microelements like copper and zinc had some correlation with the severity of dementia. |
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