Vascular endothelial growth factor B, a novel growth factor for endothelial cells. |
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| Authors: | B Olofsson K Pajusola A Kaipainen G von Euler V Joukov O Saksela A Orpana R F Pettersson K Alitalo U Eriksson |
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| Affiliation: | Ludwig Institute for Cancer Research, Stockholm, Sweden. |
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| Abstract: | ![]()
We have isolated and characterized a novel growth factor for endothelial cells, vascular endothelial growth factor B (VEGF-B), with structural similarities to vascular endothelial growth factor (VEGF) and placenta growth factor. VEGF-B was particularly abundant in heart and skeletal muscle and was coexpressed with VEGF in these and other tissues. VEGF-B formed cell-surface-associated disulfide-linked homodimers and heterodimerized with VEGF when coexpressed. Conditioned medium from transfected 293EBNA cells expressing VEGF-B stimulated DNA synthesis in endothelial cells. Our results suggest that VEGF-B has a role in angiogenesis and endothelial cell growth, particularly in muscle. |
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