| 四川省藏汉肥胖与正常人群肠道菌群及粪便胆汁酸差异研究 |
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| 引用本文： | 洪泽慧,罗若城,董科,邓羽丰,何方婷,陈静娴,左浩江,赵星,裴晓方,' target='_blank'>.四川省藏汉肥胖与正常人群肠道菌群及粪便胆汁酸差异研究[J].现代预防医学,2022,0(23):4351-4357. |
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| 作者姓名： | 洪泽慧 罗若城 董科 邓羽丰 何方婷 陈静娴 左浩江 赵星 裴晓方 ' target='_blank'> |
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| 作者单位： | 1.四川大学华西公共卫生学院/华西第四医院，四川 成都610041；2.四川大学华西-协和陈志潜卫生健康研究院 |
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| 摘 要： | 目的 研究四川省藏族及汉族肥胖人群与正常人群肠道菌群和粪便胆汁酸的差异，为调节肠道菌群预防和改善肥胖积累资料。 方法 调查四川省红原藏族居民和成都汉族居民的基本信息，采集粪便样本。依据纳入排除标准，使用基于年龄和性别的倾向性评分匹配方法纳入114名研究对象。根据BMI分为藏汉肥胖组（BMI≥28kg/m2）、正常组（18.5kg/m2≤BMI≤24kg/m2）。测定肠道菌群16S rRNA基因序列及粪便中13种胆汁酸含量，比对分析藏汉肥胖人群与正常人群肠道菌群结构、丰度及粪便胆汁酸水平差异。 结果 藏族正常组较藏族肥胖组的疣微菌门、阿克曼菌属、埃希氏菌属和拟杆菌属的丰度高，多尔氏菌属的丰度低（P＜0.05）。藏族人群中优势菌属为普雷沃氏菌属和乳杆菌属，汉族人群中优势菌属为布劳特氏菌属。藏族人群初级胆汁酸、初级胆汁酸/次级胆汁酸、结合型胆汁酸水平均低于汉族人群（P＜0.05）。 结论 藏族肥胖人群与藏族正常人群肠道菌群有一定差异，藏汉人群肠道菌群结构和物种丰度以及粪便胆汁酸谱显著不同，不同民族肥胖与肠道菌群的关联有待结合生活环境和饮食习惯进一步探讨。
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| 关 键 词： | 肥胖 肠道菌群 胆汁酸 藏族 汉族 |
Differences of gut microbiota and bile acids in Tibetan and Han obese and healthy people |
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| HONG Ze-hui,LUO Ruo-cheng,DONG ke,DENG Yu-feng,HE Fang-ting,CHEN Jing-xian,ZUO Hao-jiang,ZHAO Xing,PEI Xiao-fang.Differences of gut microbiota and bile acids in Tibetan and Han obese and healthy people[J].Modern Preventive Medicine,2022,0(23):4351-4357. |
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| Authors: | HONG Ze-hui LUO Ruo-cheng DONG ke DENG Yu-feng HE Fang-ting CHEN Jing-xian ZUO Hao-jiang ZHAO Xing PEI Xiao-fang |
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| Affiliation: | *West China School of Public Health/West China No. 4 Hospital, Sichuan University, Chengdu, Sichuan 610041, China |
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| Abstract: | Objective To clarify the differences of gut microbiota and fecal bile acids in Chengdu Han people and Hongyuan Tibetan people and to collect data for improvement of obesity prevention. Methods Basic information and stool samples were collected from Tibetan and Han people in Sichuan province. A total of 114 matched subjects were selected by Propensity Score Matching based on our inclusion and exclusion criteria. The subjects were then divided into 4 groups which were Tibetan and Han obese group (BMI≥28kg/m2) and Tibetan and Han healthy group (18.5kg/m2≤BMI≤24kg/m2). The 16S rRNA gene sequence and the contents of 13 types of bile acids were determined. The composition and relative abundance of gut microbiota and fecal bile acid content were compared between the groups. Results Relative abundance of Verrucomicrobia, Akkermansia, Escherichia and Bacteroides in Tibetan healthy group were higher than those in Tibetan obese group, while the relative abundance of Dorea was lower（P＜0.05）. Prevotella and Lactobacillus are the predominant bacteria in Tibetan, while Blautia is the predominant bacteria in Han. The levels of primary bile acids, combined bile acids and primary bile acid/secondary bile acid ratio in Tibetan were lower than those in Han（P＜0.05）. Conclusion Relative abundance of gut microbiota differs between Tibetan obese and healthy people. And there are differences in the composition and relative abundance of gut microbiota and fecal bile acids between Tibetan and Han populations. The relationship between obesity and gut microbiota in different ethnic groups remains to be further explored in combination with their living environment and dietary habits. |
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| Keywords: | Obesity Gut microbiota Bile acids Tibetan Han |
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