| 心血管病高危人群早发家族史与脑卒中的关联 |
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| 引用本文： | 程亭亭,苏健,覃玉,崔岚,丁帅,缪伟刚,周金意,武鸣.心血管病高危人群早发家族史与脑卒中的关联[J].中华疾病控制杂志,2020,24(10):1129-1133. |
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| 作者姓名： | 程亭亭 苏健 覃玉 崔岚 丁帅 缪伟刚 周金意 武鸣 |
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| 作者单位： | 210000 南京, 东南大学公共卫生学院流行病与卫生统计学系 |
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| 摘 要： | 目的 了解心血管病高危人群的脑卒中早发家族史对脑卒中患病风险的影响。 方法 基于2015年9月至2019年6月中国心血管病高危人群早期筛查与综合干预项目（China PEACE-MPP）江苏省22 552名心血管病高危人群数据，采用Logistic回归分析模型研究早发家族史对脑卒中患病的影响，并进一步进行早发家族史与高血压、糖尿病的交互作用分析。 结果 与无早发家族史人群相比，有脑卒中早发家族史的人群患脑卒中的风险较高，OR值为2.04（95% CI:1.70~2.44）；对于缺血性脑卒中的发病风险来说，男性亲属型、女性亲属型和双性亲属型皆比无早发家族史人群患病风险高，OR值分别为2.18（95% CI:1.68~2.84）、1.76（95% CI:1.3~2.37）和3.12（95% CI:1.80~5.42）；对于出血性脑卒中患病风险来说，只有女性亲属型人群与脑卒中无统计学意义。研究未发现早发家族史与高血压、糖尿病存在交互作用。 结论 有脑卒中早发家族史的心血管病高危人群发生脑卒中的风险较高，应当及早开展生活方式干预和疾病的治疗管理。
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| 关 键 词： | 心血管病高危人群 早发家族史 脑卒中 |
| 收稿时间： | 2020-05-19 |
Association between early-onset family history and stroke prevalence in high-risk populations of cardiovascular disease |
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| Affiliation: | Department of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing 210000, China |
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| Abstract: | Objective To investigate how the early-onset family history of stroke influences the stroke in high-risk populations of cardiovascular disease. Methods Based on the China Patient-centered Evaluative Assessment of Cardiac Events Million Persons Project (China PEACE-MPP) from 2015 to 2019, a total of 22 552 persons at high-risk for cardiovascular disease (CVD) were selected from eight project areas in Jiangsu. Logistic regression analysis model was used to research the impact of early-onset family history on stroke prevalence, and further analyses of the interaction between early-onset family history and hypertension or diabetes were carried on. Results Compared with people without early-onset family history, people with early-onset family history of stroke had a higher risk of stroke, with an OR value of 2.04 (95% CI:1.70-2.44). For the risk of ischemic stroke, people whose only male relatives, only female relatives and bisexual relatives suffering from stroke had a higher risk of stroke than those without early onset family history, with OR values of 2.18 (95% CI:1.68-2.84), 1.76 (95% CI:1.31-2.37) and 3.12 (95% CI:1.80-5.42), respectively. For the risk of hemorrhagic stroke, only female relatives type was not significant. No interaction between early-onset family history or hypertension and diabetes was found. Conclusions People at high risk of CVD with the early-onset family history have a higher risk of stroke. Lifestyle intervention and disease management should be carried out opportunely. |
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