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| 丁苯酞软胶囊与艾地苯醌在血管性痴呆老年患者中的临床价值 | |
| 引用本文： | 李玉凤. 丁苯酞软胶囊与艾地苯醌在血管性痴呆老年患者中的临床价值[J]. 国际医药卫生导报, 2022, 28(4): 471-474. DOI: 10.3760/cma.j.issn.1007-1245.2022.04.007 |
| 作者姓名： | 李玉凤 |
| 作者单位： | 鹤壁朝阳仁爱医院神经内科，鹤壁 456750 |
| 基金项目： | 河南省医学科技攻关项目（20170101210） |
| 摘 要： | 目的:探讨丁苯酞联合艾地苯醌治疗血管性痴呆老年患者的临床价值。方法:回顾性分析，选取鹤壁朝阳仁爱医院2020年1月至2021年6月收治的165例血管性痴呆老年患者作为研究对象，分析患者病历资料后根据用药方案的不同将所有患者分为对照组（82例）和研究组（83例）。对照组男42例、女40例，年龄（69.27±2.51）岁；... |
| 关 键 词： | 血管性痴呆 老年患者 丁苯酞 艾地苯醌 血液流变学 |
| 收稿时间： | 2021-11-03 |
Application effect of butylphthalide soft capsules and idebenone in elderly patients with vascular dementia |
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| Li Yufeng. Application effect of butylphthalide soft capsules and idebenone in elderly patients with vascular dementia[J]. International Medicine & Health Guidance News, 2022, 28(4): 471-474. DOI: 10.3760/cma.j.issn.1007-1245.2022.04.007 | |
| Authors: | Li Yufeng |
| Affiliation: | Departmentof Neurology, Hebi Chaoyang Ren'ai Hospital, Hebi 456750, China |
| Abstract: | Objective To explore the clinical value of butylphthalide combined with idebenonein the treatment of elderly patients with vascular dementia. Methods The retrospective analysis selected 165 elderlypatients with vascular dementia admitted to Hebi Chaoyang Ren'ai Hospital fromJanuary 2020 to June 2021 as the research objects. After analyzing thepatients' medical records, all patients were divided into a control group (82cases) and a study group (83 cases) according to different medication regimens.There were 42 males and 40 females in the control group, aged (69.27±2.51)years; there were 44 males and 39 females in the study group, aged (69.50±2.76)years. The control group received butylphthalide treatment, the study groupreceived butylphthalide combined with idebenone treatment, and both groups weretreated for 2 months. The carotid peak systolic velocity (PSV), MontrealCognitive Assessment Scale (MoCA) score, resistance index (RI), Stroke SpecialQuality of Life Scale (SS-QOL) score, and end diastolic velocity (EDV) beforeand after treatment and adverse reactions were compared between the two groups.Independent sample t test was usedfor inter-group comparison of the measurement data, paired t test was used for intra-group comparison of the measurement data,and χ2 test was used forthe count data. Results The MoCA score of thestudy group after treatment was higher than that of the control group[(23.43±2.75) points vs. (19.79±2.91) points], with a statistically significantdifference (P<0.05). Beforetreatment, there were no statistically significant differences in the carotidhemodynamic indexes between the two groups (all P>0.05); after treatment, the EDV and PSV of the study groupwere (19.93±4.96) cm/s and (75.95±10.25) cm/s, respectively, higher than thoseof the control group [(17.55±5.21) cm/s and (70.16±15.16) cm/s], the RI was(0.60±0.07), lower than that of the control group [(0.66±0.17)], withstatistically significant differences (all P<0.05).Before treatment, there was no statistically significant difference in theSS-QOL score between the two groups (P>0.05);after treatment, the scores of self-care ability, physical state, psychologicalstate, and life impact of SS-QOL of the study group were (49.35±8.16) points,(52.35±9.44) points, (39.86±6.28) points, and (40.13±5.52) points,respectively, which were higher than those of the control group [(43.55±7.84)points, (46.61±8.93) points, (34.34±6.55) points, and (35.41±6.15) points],with statistically significant differences (all P<0.05). There was no statistically significant difference inthe incidence of adverse reactions between the two groups (P>0.05). Conclusion Butylphthalidecombined with idebenone can effectively improve the hemodynamic indexes ofcerebral artery in elderly patients with vascular dementia, and improve theirquality of life and MoCA score. |
| Keywords: | Vascular dementia Elderly patients Butylphthalide Idebenone Hemorheology |
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