| 凝血功能指标及血小板参数与子痫前期的相关性研究 |
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| 引用本文： | 赵花,田玲,沈禾,王倩,单婉君,吴梦丽.凝血功能指标及血小板参数与子痫前期的相关性研究[J].蚌埠医学院学报,2020,45(7):883-887. |
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| 作者姓名： | 赵花 田玲 沈禾 王倩 单婉君 吴梦丽 |
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| 作者单位： | 1.蚌埠医学院 研究生院, 安徽 蚌埠 2330302.蚌埠医学院附属蚌埠市第三人民医院 妇产科, 安徽 蚌埠 233000 |
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| 基金项目： | 蚌埠市科技局创新项目2019（90） |
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| 摘 要： | 目的分析病人凝血功能指标及血小板参数，探讨其对子痫前期（PE）的临床意义。方法选取符合PE诊断的孕妇78例为观察组，并按照发病时间分为观察组1（早发型PE组，孕周20~ < 34周）和观察组2（晚发型PE组，孕周≥34周）。同时选取产检的健康孕妇80例作为对照组，对照组同样按照孕周分为对照组1（孕周20~ < 34周）和对照组2（孕周≥34周）。所有受试者采血和测血压，检测凝血功能指标、血小板参数。采用Pearson相关分析验证D-二聚体（D-D）与凝血功能指标之间的关系。结果观察组1的体质量指数（BMI）、D-D、收缩压（SBP）、舒张压（DBP）、平均血小板体积（MPV）、血小板分布宽度（PDW）值高于对照组1（P < 0.01）。观察组2 BMI、SBP、DBP值高于对照组2（P < 0.01）。观察组1 D-D值高于观察组2（P < 0.01）。对照组2 BMI、D-D、DBP、MPV水平高于对照组1（P < 0.05~P < 0.01）。观察组BMI、D-D、SBP、DBP、MPV水平高于对照组（P < 0.01）。观察组1凝血酶原时间（PT）、国际标准化比值（INR）、活化部分凝血酶原时间（APTT）、血浆纤维蛋白原（FIB）、凝血酶时间（TT）水平与对照组1比较差异有统计学意义（P < 0.05~P < 0.01）。观察组2 PT、INR、FIB、TT水平与对照组2比较差异有统计学意义（P < 0.01）。观察组1 TT与观察组2比较差异有统计学意义（P < 0.05）。对照组1 FIB、TT与对照组2比较差异有统计学意义（P < 0.01）。观察组PT、INR、APTT、FIB、TT水平与对照组比较差异有统计学意义（P < 0.01）。PE病人D-D与孕周、PT、INR、APTT、TT、PLT均呈负相关关系（r=-0.289、-0.235、-0.247、-0.236、-0.351、-0.286，P < 0.05~P < 0.01）。PE病人D-D与FIB、MPV、PDW无明显相关性（P>0.05）。结论早发型PE病人高凝血状态较晚发型PE病人更为明显，PE病人D-D与凝血功能密切相关，D-D可以作为预测PE发病的生物学标志物。
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| 关 键 词： | 子痫前期 D-二聚体 凝血功能 血小板参数 |
| 收稿时间： | 2019-09-30 |
Correlation between coagulation function,platelet parameters and preeclampsia |
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| Affiliation: | 1.School of Graduate, Bengbu Medical College, Bengbu Anhui 2330302.Department of Obstetrics and Gynecology, The Third People's Hospital of Bengbu Affiliated to Bengbu Medical College, Bengbu Anhui 233000, China |
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| Abstract: | ObjectiveTo analyze the coagulation function index and platelet parameters of patients, and explore their clinical significance in preeclampsia (PE).MethodsSeventy-eight pregnant women with PE were set as the observation group, and subdivided into the observation group 1 (early PE group, 20 weeks ≤gestational weeks < 34 weeks) and observation group 2 (late PE group, onset ≥34 weeks).At the same time, 80 healthy pregnant women were set as the control group, and subdivided into the control group 1 (20 weeks ≤gestational weeks < 34 weeks) and control group 2 (onset ≥34 weeks).The blood of all cases was collected, and the blood pressure was measured.The indicators of coagulation function and platelet parameters were detected.The correlation between D-dimer (D-D) and coagulation function indexes were analyzed using the Pearson test.ResultsThe body mass index (BMI), D-D, systolic pressure (SBP), diastolic pressure (DBP), mean platelet volume (MPV) and platelet distribution width (PDW) in observation group 1 were higher than those in control group 1 (P < 0.01).The BMI, SBP and DBP in observation group 2 were higher than those in control group 2 (P < 0.01).The D-D in observation 1 group was higher than that in observation group 2 (P < 0.01).The levels of BMI, D-D, DBP and MPV in control group 2 were higher than those in control group 1 (P < 0.05 to P < 0.01).The levels of BMI, D-D, SBP, DBP and MPV in observation group were higher than those in control group (P < 0.01).The differences of the levels of PT, INR, APTT, FIB and TT between the observation group 1 and control group 1 were statistically significant (P < 0.05 to P < 0.01).The differences of the levels of PT, INR, FIB and TT between the observation group 2 and control group 2 were statistically significant (P < 0.01).The difference of the level of TT between the observation group 1 and observation group 2 was statistically significant (P < 0.05).The differences of the levels of FIB and TT between the control group 1 and control group 2 were statistically significant (P < 0.01).The differences of the levels of PT, INR, APTT, FIB and TT between the observation group and control group were statistically significant (P < 0.01).The D-D in PE patients was negatively correlated with the levels of gestational weeks, PT, INR, APTT, and TT (r=-0.289, -0.235, -0.247, -0.236, -0.351, -0.286, P < 0.05 to P < 0.01), and the D-D was not correlated with the levels of FIB, MPV, and PDW in PE patients (P>0.05).ConclusionsThe high coagulation status in early PE patients is more obvious than that in late PE patients.The D-D in PE patients is closely related to coagulation function, and the D-D can be used as a biological marker to predict the incidence of PE. |
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