Evaluation of Haptoglobin Genotype and Some Risk Factors of Cancer in Patients with Early Stage Esophageal Cancer |
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| Authors: | Sara Hosseinzadeh1Reza Alipanah-Moghadam1Fazel Isapanah Amlashi2Ali Nemati1 |
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| Affiliation: | 1Department of Clinical Biochemistry, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.2Student Research Committee, Golestan University of Medical Sciences, Gorgan, Iran. |
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| Abstract: | Introduction: Esophageal cancer is one of the most lethal gastrointestinal cancers that has a complex and diverseetiology, with several genetic and nutritional factors involved in its etiology. The purpose of this study was to investigatethe type of haptoglobin genotype and its relationship with some nutritional and biochemical risk factors affectingthe prevalence of esophageal cancer in patients with early stage esophageal cancer. Materials and methods: In thisstudy, 44 patients (20 males and 24 females) with early stage esophageal cancer and 44 healthy subjects, classified ascontrol group, (19 males and 25 females) were selected. Haptoglobin (HP) genotype was determined employing PCRtechnique. Nutritional data were analyzed using standard food frequency questionnaire (FFQ) method. Serum levelsof malondialdehyde (MDA), nitrate and nitrite were measured employing the colorimetric method. Serum levels ofp53 protein were measured using the enzyme-linked immunosorbent assay (ELISA) technique. Results: The resultsof our study showed for the first time that HP1-1 genotype was the most prevalent genotype in esophageal cancerpatients in Golestan province, Iran. HP2-2 genotype was the most frequent in the control group. Serum levels of MDAwere significantly higher in the patients’ group compared to the control group (P˂0.001). Weight and body mass index(BMI) were significantly lower in the patients’ group than the control group (P<0.01). Food frequency analysis revealedthat the consumption of fruits and vegetables in the patients’ group was lower than that of the control group (P<0.05).Conclusion: The results of our study showed for the first time that HP1-1 genotype is the dominant genotype inpatients with esophageal cancer in Golestan province. As well, modification of nutritional pattern and consumption ofhigh level of antioxidant compounds can be effective in reducing the prevalence of esophageal cancer in this region. |
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| Keywords: | Esophageal Cancer Haptoglobingenotype Cancer risk factors |
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