| 中国北方汉族人群IL-8基因+394 T/G多态性与急性冠脉综合征的关联性 |
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| 引用本文： | 张效林,张保海,梁振洋,孙莹,冯雪瑶,韩雅玲. 中国北方汉族人群IL-8基因+394 T/G多态性与急性冠脉综合征的关联性[J]. 心脏杂志, 2012, 24(4): 442-445 |
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| 作者姓名： | 张效林 张保海 梁振洋 孙莹 冯雪瑶 韩雅玲 |
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| 作者单位： | (沈阳军区总医院心内科，辽宁 沈阳 110084) |
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| 基金项目： | 军队临床高新技术重大项目资助(2010GXJS001);国家自然科学基金青年科学基金项目资助(81100135) |
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| 摘 要： | 目的:观察趋化因子白介素-8（Interleukin-8，IL-8)基因单核苷酸多态性与急性冠脉综合征（acute coronary syndrome,ACS）的相关性。方法: 采用直接测序的方法对675例ACS的患者和636例对照组进行检测，分析IL-8基因+394T/G单核苷酸多态的基因型和等位基因频率的分布情况。结果: IL-8基因+394 T/G单核苷酸多态在ACS组和对照组间的分布频率皆符合Hardy-Weinberg平衡定律，IL-8基因+394 T/G单核苷酸多态三种基因型（GG型，GT型和TT型）在ACS组分布频率分别为16.9%，48.7%和34.4%，在对照组分别为18.1%，50.9%和31.0%。IL-8基因+394 T/G多态基因型和等位基因频率在正常对照组和ACS组之间无明显的相关(P>0.05)。Logistic回归校正性别、年龄、体质量指数、吸烟、高血压病、高脂血症、糖尿病等冠心病易患因素后，IL-8基因+394 T/G多态与ACS的发病无相关关系。结论: 在中国北方汉族人群中IL-8基因+394T/G多态与ACS发病无相关关系，IL-8基因+394 T/G 多态不是ACS发病的独立危险因素。
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| 关 键 词： | 冠状动脉疾病 急性冠脉综合征 基因 单核苷酸多态性 |
| 收稿时间： | 2011-11-27 |
Association of interleukin-8 +394 T/G with acute coronary syndrome in a Han population in Northern China |
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| ZHANG Xiao-lin,ZHANG Bao-hai,LIANG Zhen-yang,SUN Ying,FENG Xue-Yao,HAN Ya-ling. Association of interleukin-8 +394 T/G with acute coronary syndrome in a Han population in Northern China[J]. Chinese Heart Journal, 2012, 24(4): 442-445 |
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| Authors: | ZHANG Xiao-lin ZHANG Bao-hai LIANG Zhen-yang SUN Ying FENG Xue-Yao HAN Ya-ling |
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| Affiliation: | (Department of Cardiology,Shenyang General Hospital,Shenyang Military Area Command,Shenyang 110084,Liaoning,China) |
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| Abstract: | AIM: To investigate the association between IL-8 +394T/G polymorphism and acute coronary syndrome(ACS) in a Han population in Northern China.METHODS: A case-control study was conducted in 675 patients with ACS and 636 controls with normal coronary angiograms.Polymorphic genotypes were determined by polymerase chain reaction and sequencing analysis.RESULTS: Genotype frequencies in IL-8 +394 T/G polymorphism were in good concordance with the Hardy-Weinberg equilibrium in both case and control groups.Genotype frequencies of GG,GT and TT of IL-8 +394 T/G polymorphism were 18.1%,50.9% and 31.0% in the controls,and 16.9%,48.7% and 34.4% in patients with ACS,respectively.There were no significant differences in the genotype and allele distribution of +394 T/G polymorphism of the IL-8 gene between groups(P>0.05).Logistic regression analysis with adjustments for other risk factors revealed that the IL-8 +394 T/G allele carriers did not significantly increase the risks of ACS compared with noncarriers(P>0.05).CONCLUSIONS: IL-8 +394 T/G polymorphism was not a genetic risk factor for ACS in a Han population in Northern China. |
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| Keywords: | coronary disease acute coronary syndrome gene polymorphism |
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