| 水蛭抗凝血活性物质分析及水蛭素提取纯化的研究进展 |
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| 引用本文： | 孙雨,王宇维,刘锦瑜,等. 水蛭抗凝血活性物质分析及水蛭素提取纯化的研究进展[J]. 神经药理学报, 2021, 11(5): 30. DOI: 10.3969/j.issn.2095-1396.2021.05.005 |
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| 作者姓名： | 孙雨 王宇维 刘锦瑜 等 |
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| 作者单位： | 1. 河北北方学院药学系，张家口，075000，中国 2. 河北北方学院基础医学院，张家口，075000，中国 |
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| 基金项目： | 大中学生科技创新能力培育专项（No.2021H070302） |
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| 摘 要： | 水蛭是一味传统的中药材，水蛭素是从水蛭体内和新鲜唾液中提取的天然多肽，具有抗凝血作用，在临床上广泛应用，但并不是所有品种的水蛭体内都含有水蛭素。该文综述了几种常见水蛭中含有的抗凝血活性物质成分以及水蛭素的提取和纯化方法，旨在为高效快速提取水蛭素的方法的深入研究提供参考和借鉴。
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| 关 键 词： | 抗凝血活性物质 水蛭素 提取 纯化 |
Research Progress in the Analysis of Anticoagulant Active Substances in Leeches and the Extraction and Purification of Hirudin |
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| SUN Yu,WANG Yu-wei,LIU Jin-yu,et al. Research Progress in the Analysis of Anticoagulant Active Substances in Leeches and the Extraction and Purification of Hirudin[J]. Journal of Hebei North University(Medical Edition), 2021, 11(5): 30. DOI: 10.3969/j.issn.2095-1396.2021.05.005 |
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| Authors: | SUN Yu WANG Yu-wei LIU Jin-yu et al |
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| Affiliation: | 1. Department of Pharmacy，Hebei North University，Zhangjiakou，075000，China 2. School of Basic Medicine，Hebei North University，Zhangjiakou，075000，China |
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| Abstract: | Leech is a traditional Chinese herbal medicine. Hirudin is a natural polypeptide extracted from leeches and fresh saliva，which has anticoagulant effects and is widely used clinically，but not all varieties of leeches contain hirudin in the body. This article reviews the anticoagulant active substance components contained in several common leeches and the extraction and purification methods of hirudin，aiming to provide reference and reference for in-depth research on the method of efficient and rapid extraction of hirudin. |
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| Keywords: | anticoagulant active substance hirudin extraction purification |
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