Title:

Relationship between AZFc area gr/gr and male oligozoospermia and azoospermia:a systematic review and meta-analysis

作者：

张明哲, 姚观平, 刁英, 董世桃, 罗克燕

张明哲,姚观平,刁英,董世桃,罗克燕

Author(s):

ZHANG Ming-zhe, YAO Guan-ping, DIAO Ying, DONG Shi-tao, LUO Ke-yan

ZHANG Ming-zhe,YAO Guan-ping,DIAO Ying,DONG Shi-tao,LUO Ke-yan

单位:

贵州省遵义医科大学附属医院生殖中心,贵州 遵义 563003

Unit:

Department of Reproductive Centre,The Affiliated Hospital of Zunyi Medical University,Zunyi,Guizhou 563003,China

关键词:

AZFc区域; 微缺失; 少精症; 无精症; meta分析

AZFc区域;微缺失;少精症;无精症;meta分析

Keywords:

AZFc region; Microdeletion; Oligozoospermia; Azoospermia; Meta-analysis

分类号:

R181.3+2

文献标识码:

A

摘要:

目的 定量系统评价Y染色体AZFc区gr/gr微缺失与少精和无精症的关系。方法 联合应用NCBI PubMed、中国知网(CNKI)、万方等数据库,检索gr/gr及DAZ微缺失与男性少精和无精症的病例-对照研究,截止时间2018年5月31日。应用Stata12.0软件,计算合并风险比值比(odds ratio,OR)及其置信区间(confidence interval,95%CI),评估AZFc区微缺失与少精和无精症的关联。结果 研究共纳入19篇合格文献,包含研究对象8464例,其中病例组5155例、对照3309例。Stata合并分析结果显示,gr/gr微缺失与男性少精子症(oligozoospermia,OZ)显著关联,病例组缺失率显著高于对照组,OR及其95%CI为1.61(1.06~2.44);未发现gr/gr缺失与无精症(azoospermia,AZ)的发生存在显著关联,OR及其95%CI为1.23(0.85~1.79)。结论 AZFc区gr/gr微缺失可能是男性少精症发生的独立遗传因素。

Abstract:

Objective To quantitatively and systematically evaluate the relationship between gr/gr microdeletion in AZFc region of the Y chromosome and oligospermia and azoospermia.Methods A case-control study of gr/gr and DAZ microdeletions and male oligozoospermia and azoospermia was retrieved by using databases,including NCBI PubMed,CNKI and Wanfang.The deadline was 31 May,2018.Stata 12.0 software was used to calculate the odds ratio(OR)and its confidence interval(95%CI)to assess the association of AZFc microdeletion with oligozoospermia and azoospermia.Results A total of 19 eligible articles were included,including 8464 subjects(5155 cases and 3309 controls).Stata combined analysis showed that,gr/gr microdeletion in AZFc region was significantly associated with oligozoospermia(OZ),the deletion rate in case group was significantly higher than that in control group,OR and 95% CI were 1.61(1.06-2.44).However,no significant association was found between gr/gr and azoospermia(AZ),OR and 95% CI were 1.23(0.85-1.79).Conclusion Y chromosome AZFc gr/gr microdeletion may be the independent genetic factors of oligozoospermia in males.

参考文献
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备注/Memo:

基金项目:贵州省科学技术基金项目[黔科合LH字(2014)7569号]
作者简介:张明哲(1982-),男,硕士,研究方向:生殖内分泌及辅助生殖技术研究