| 肠道微生态影响动脉粥样硬化发生发展的机制 |
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| 引用本文： | 张田田,王长谦.肠道微生态影响动脉粥样硬化发生发展的机制[J].心脏杂志,2017,29(5):614-616. |
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| 作者姓名： | 张田田 王长谦 |
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| 作者单位： | （上海交通大学医学院附属第九人民医院心内科，上海 200011） |
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| 基金项目： | 助（81470546）；高等学校博士学科点专项科研基金项目资助（20130073110016）；上海市进一步加快中医药事业发展三年行动计划(2014年-2016年)项目资助（ZY3-CCCX-3-3002）
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| 摘 要： | 动脉粥样硬化(AS)不仅是一种炎症性疾病,而且属于一种代谢性疾病。肠道微生态的改变可对AS的发生发展产生双面影响。一方面,肠道菌群紊乱可以通过影响机体的胆碱代谢、氧化应激、炎症反应等机制直接促进AS产生发展,此外,可通过导致AS危险因素肥胖、高脂血症、糖尿病等的产生这些间接机制促AS的进展。另一方面,益生菌及益生元的增加则可有效地降低肠道微生物内毒素产生、增强肠道屏障、减轻机体质量、缓解炎症反应、改善胰岛素抵抗,进而在AS的进展方面发挥重要作用。因此,合理调控机体肠道微生态环境成为AS防治的新型重要手段。
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| 关 键 词： | ,,,,,,, |
| 收稿时间： | 2016-04-29 |
The mechanism of intestinal microecosystem effects on atherogenesis |
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| Abstract: | Atherosclerosis is not only an inflammatory disease, but also a metabolic disease. The change of intestinal microecosystem can make double effects on atherogenesis. On the one hand, disordered intestinal microbes may accelerate atherogenesis through directly disturbing choline metabolism, oxidative stress, inflammation and so on. In addition, they could promote the development of atherosclerosis risk factors such as obesity, hyperlipidemia, and diabetes, which indirectly lead to atherogenesis. On the other hand, the increase of probiotics and prebiotics in the intestinal tract can effectively decrease the generation of endotoxin from intestinal microbes, enhance the barrier function, relieve body weights, remit inflammation, ameliorate the insulin resistance, thus to elimate the development of atherosclerosis. Therefore, reasonable adjustment of intestinal microecosystem will become an novel important prevention and therapy method for atherosclerosis. |
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