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| 含三氧化二砷方案治疗复发难治性非M3急性非淋巴细胞白血病45例疗效观察 | |
| 引用本文： | 姚亚洲,李小妮,郑引索. 含三氧化二砷方案治疗复发难治性非M3急性非淋巴细胞白血病45例疗效观察[J]. 现代肿瘤医学, 2015, 0(20): 3030-3032. DOI: 10.3969/j.issn.1672-4992.2015.20.45 |
| 作者姓名： | 姚亚洲 李小妮 郑引索 |
| 作者单位： | 宝鸡市中心医院血液风湿病科，陕西 宝鸡 721000 |
| 摘 要： | 目的:回顾性分析三氧化二砷联合LD-HA治疗难治性非M3急性非淋巴细胞白血病的疗效及不良反应。方法:应用三氧化二砷(0.15mg·kg﹣1·d﹣1，d1~5，d8~12)+ LD-HA(高三尖杉酯碱1mg/d，阿糖胞苷25mg，2次/d，d1~14治疗。ANC（中性粒细胞计数）<1.0×109／L时使用粒细胞集落刺激因子(G-CSF)5μg·kg﹣1·d﹣1，直至ANC>1.0×109／L。结果:一个疗程的总有效率达91.1％，其中CR 32例(71.1％),PR 9例(20％)，NR 4例(8.9％)。不良反应轻微。结论:三氧化二砷联合LD-HA治疗难治性非M3急性非淋巴细胞白血病安全有效。 |
| 关 键 词： | 三氧化二砷 复发难治性急性非淋巴细胞白血病 疗效 |
Clinical analysis of As2 O3 and low dose Homoharringtonine -cytarabine in the treatment of 45 patients with refractory or relapsed non -M3 acute non -lymphocytic leukemia |
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| Yao Yazhou,Li Xiaoni,Zheng Yinsuo. Clinical analysis of As2 O3 and low dose Homoharringtonine -cytarabine in the treatment of 45 patients with refractory or relapsed non -M3 acute non -lymphocytic leukemia[J]. Journal of Modern Oncology, 2015, 0(20): 3030-3032. DOI: 10.3969/j.issn.1672-4992.2015.20.45 | |
| Authors: | Yao Yazhou Li Xiaoni Zheng Yinsuo |
| Affiliation: | Department of Blood and Rheumatic Diseases,The Central Hospital of Baoji，Shaanxi Baoji 721000，China. |
| Abstract: | Objective:To observe the therapeutic outcome and adversere effect of the combined As2O3 with low-dose homoharringtonine-cytarabine(LD-HA) in the treatment of refractory or relapsed non-M3 acute non-lymphocytic leukemia．Methods:All the patients was treated with As2O3(0.15mg·kg﹣1·d﹣1，d1~5，d8~12) and LD-HA with homoharringtonine 1mg/d and Ara-C 25mg，per 12h，d1~14.Granulocyte colony-stimulating factor(G-CSF,5μg·kg﹣1·d﹣1) was used when the absolute neutrophil count were counted less than 1.0×109/L．Results:After one course of therapy，total efficiency rate of relapsed non-M3 acute non-lymphocytic leukemia was 91.1%，in which the complete remission (CR) were 32 cases（71.1％）,partial response were 9 cases（20％）,non-remission were 4 cases（8.9％），without any great side effect.Conclusion:The combination of As2O3 and LD-HA scheme had higher CR rate and fewer adverse action in the treatment of refractory or relapsed acute non-lymphocytic leukemia patients． |
| Keywords: | arsenic trioxide refractory or relapsed non-M3 acute non-lymphocytic leukemia efficacy |
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