High levels of susceptibility and T helper 2 response in MyD88-deficient mice infected with Leishmania major are interleukin-4 dependent |
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| Authors: | Debus Andrea Gläsner Joachim Röllinghoff Martin Gessner André |
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| Affiliation: | Institut für Klinische Mikrobiologie, Immunologie und Hygiene der Universit?t Erlangen-Nürnberg, 91054 Erlangen, Germany. |
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| Abstract: | ![]()
Myeloid differentiation protein 88 (MyD88) is a general adaptor for the signaling cascade through receptors of the Toll/IL-1R family. When infected with Leishmania major parasites, MyD88-deficient mice displayed a dramatically enhanced parasite burden in their tissues similar to that found in susceptible BALB/c mice. In contrast, MyD88 knockout mice did not develop ulcerating lesions despite a lack of interleukin-12 (IL-12) production and a predominant T helper 2 cell response. Blockade of IL-4 produced early (day 1) after infection restored a protective T helper 1 response in MyD88 knockout mice. |
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