| 1岁以下婴幼儿血清乙肝病毒血清标志物检测结果分析 |
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| 引用本文： | 安哲,李思鹏,张妮,董炜,孟昊,刘海龙,周源,郭智,秦瑞鸿,朱幻歌,宋琳岚.1岁以下婴幼儿血清乙肝病毒血清标志物检测结果分析[J].中华全科医学,2022,20(1):99-103. |
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| 作者姓名： | 安哲 李思鹏 张妮 董炜 孟昊 刘海龙 周源 郭智 秦瑞鸿 朱幻歌 宋琳岚 |
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| 作者单位： | 西安交通大学第二附属医院检验科，陕西 西安 710004 |
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| 基金项目： | 陕西省重点研发计划项目(2018SF-152);西安交通大学第二附属医院人才培养专项科研青年基金[YJ(QN)201534]。 |
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| 摘 要： | 目的 回顾性分析1周岁前婴幼儿血清乙肝病毒血清标志物检测结果及其特征.方法 以2019年1-11月在西安交通大学第二附属医院临床实验室检测乙肝病毒血清标志物(hepatitis B virus markers,HBV-M)的815例1岁以下婴幼儿和219例新生儿母亲为研究对象.将1岁以下内婴幼儿按月龄分为3组:7 ～1...
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| 关 键 词： | 婴幼儿 乙肝病毒血清标志物 乙型肝炎表面抗原 疫苗 |
| 收稿时间： | 2020-04-09 |
Epidemiological study on the HBV-M results in infants under 1 year of age in Xi'an area |
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| Authors: | AN Zhe LI Si-peng ZHANG Ni DONG Wei MENG Hao LIU Hai-long ZHOU Yuan GUO Zhi QIN Rui-hong ZHU Huan-ge SONG Lin-lan |
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| Affiliation: | Department of Clinical Laboratory, the the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, China |
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| Abstract: | Objective To analyse the results and characteristics of hepatitis B virus markers(HBV-M)in infants before 1 year of age retrospectively.Methods From January 2019 to November 2019,815 infants and 219 mothers with HBV-M were examined in the clinical laboratory of the Second Affiliated Hospital of Xi'an Jiaotong University.The infants were divided into three groups:group 1,which included infants aged 7-11 months;group 2,which included infants aged 1-6 months;and group 3,which included infants aged below 1 month.The HBV-M quantitative test was performed by chemiluminescent immunoassay with Abbott's Alinity immunoassay instrument.All samples of HBsAg were centrifuged at high speed and rechecked,and the rechecked results were taken as the final results.Results The positive rates of HBsAg were 0.00%,0.47%and 6.66%,respectively,in the three groups.The positive rates of anti-HBs in the three groups were 94.29%,84.65%and 66.06%,respectively.The positive rates of anti-HBc in the three groups were 6.67%,20.47%and 27.27%,respectively.The HBsAg positive rate was 0%in infants born from 8 HBsAg-positive mothers.The consistency rate was 85.53%between 76 HBV-M-negative mothers and their infants,and consistency rates of anti-HBs,anti-HBc and anti-HBe were 100.00%,95.00%and 77.27%,respectively.The main features of HBV-M in 31 HBsAg-positive infants were:HBsAg negative in their mothers,HBsAg level 0.19 IU/mL(0.05-0.54 IU/mL),anti-HBc negative,regular follow-up HBsAg can turn negative,HBV vaccine and NHB may be the main reason for false positive,the detection time does not exceed 10 days after vaccination.Conclusion The HBSAG positive rate and anti-HB positive rate of 7-11-month-old infants are the lowest,which indicates that the protective effect of HBV vaccine is good at present HBsAg was mainly found in 1-10-day-old newborns,which could turn negative during regular follow-up. |
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| Keywords: | Infant Hepatitis B virus markers HBsAg HBV vaccine |
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