Standardization of an experimental murine model of invasive pulmonary aspergillosis |
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| Authors: | Sheppard Donald C Graybill John R Najvar Laura K Chiang Lisa Y Doedt Thomas Kirkpatrick William R Bocanegra Rosie Vallor Ana C Patterson Thomas F Filler Scott G |
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| Affiliation: | McGill University, Department of Microbiology and Immunology, Montreal, Quebec, Canada. donald.sheppard@mcgill.ca |
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| Abstract: | Evaluating new therapeutic agents for invasive aspergillosis requires animal models that are reproducible among different laboratories. We therefore evaluated a murine model of aerosol infection in two independent laboratories and found a high level of both intra- and interlaboratory reproducibility of survival, fungal burden over time, and the efficacy of liposomal amphotericin B. |
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