| 内镜下套扎术后应用卡维地洛治疗肝硬化并发食管胃底静脉曲张破裂出血患者疗效研究 |
| |
| 引用本文： | 伍畅,张远安,彭春芬. 内镜下套扎术后应用卡维地洛治疗肝硬化并发食管胃底静脉曲张破裂出血患者疗效研究[J]. 实用肝脏病杂志, 2021, 24(3): 403-406. DOI: 10.3969/j.issn.1672-5069.2021.03.025 |
| |
| 作者姓名： | 伍畅 张远安 彭春芬 |
| |
| 作者单位： | 434200 湖北省松滋市人民医院消化内科(伍畅,张远安); 华中科技大学同济医学院附属协和医院肿瘤医院肿瘤一科(彭春芬) |
| |
| 摘 要： | 目的 探讨采取在内镜下套扎术(EVL)后应用卡维地洛治疗肝硬化食管胃底静脉曲张破裂出血(EVB)患者的疗效.方法 2017年12月～2019年12月我院收治的肝硬化并发EVB患者72例,采用随机数字表法分为对照组35例,行EVL治疗,和观察组37例,采用EVL后给予卡维地洛治疗,均随访12个月.采用ELISA法检测血清...
|
| 关 键 词： | 肝硬化 食管胃底静脉曲张破裂出血 内镜下套扎 卡维地洛 治疗 |
| 收稿时间： | 2021-01-06 |
Efficacy of endoscopic variceal ligation and carvedilol maintenance in the treatment of patients with liver cirrhosis and esophagogastric variceal bleeding |
| |
| Wu Chang,Zhang Yuan’an,Peng Chunfen. Efficacy of endoscopic variceal ligation and carvedilol maintenance in the treatment of patients with liver cirrhosis and esophagogastric variceal bleeding[J]. Journal of Clinical Hepatology, 2021, 24(3): 403-406. DOI: 10.3969/j.issn.1672-5069.2021.03.025 |
| |
| Authors: | Wu Chang Zhang Yuan’an Peng Chunfen |
| |
| Affiliation: | Department of Gastroenterology, Songzi People's Hospital, Songzi 434200, Hubei Province,China |
| |
| Abstract: | Objective The aim of this study was to observe the efficacy of endoscopic variceal ligation(EVL)and carvedilol maintenance in the treatment of patients with liver cirrhosis and complicated esophagogastric variceal bleeding(EVB).Methods A total of 72 patients with liver cirrhosis and EVB were enrolled in our hospital between December 2017 and December 2019,and were randomly divided into control(n=35),receiving EVL,and observation group(n=37),receiving carvedilol maintenance after EVL.All patients were followed-up for 12 months.Serum high-sensitivity C-reactive protein(hs-CRP),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)were detected by ELISA.Results Two and four patients in the observation and control group respectively in our series died from emergent bleeding(P>0.05);there were no significant differences in the blood transfusion volume and hemostasis time between the two groups(P>0.05),but the hospital stay in observation group was significantly shorter than that in control group[(10.4±2.4)d vs.(12.1±2.2)d,P<0.05];there were no significant differences as respect to blood routine and liver function tests at presentation and 2 weeks after treatment between the two groups(P>0.05);at admission,there were no significant differences with respect to serum CRP,IL-6 and TNF-αlevels between the two groups(P>0.05),while 2 weeks after the treatment,serum CRP,IL-6 and TNF-αlevels in the observation group were(4.9±0.32)mg/l,(20.4±9.4)pg/ml and(25.1±8.1)pg/ml,significantly lower than[(6.3±5.5)mg/l,(28.6±7.6)pg/ml and(34.7±9.3)pg/ml,respectively,P<0.05]in the control;there were no significant differences in the incidence of adverse reactions between the two groups(42.9%vs.48.4%,P>0.05);at the end of 3 months and 6 months of follow-up,the re-bleeding rates were 11.4%and 20.0%in observation group,significantly lower than 29.0%and 45.2%in the control group(P<0.05).Conclusion The carvedilol maintenance after EVL has a good efficacy in the treatment of patients with liver cirrhosis and EVB,which is worthy of further clinical investigation. |
| |
| Keywords: | Liver cirrhosis Esophagogastric variceal bleeding Endoscopic variceal ligation Carvedilol Therapy |
| 本文献已被 CNKI 维普 等数据库收录！ |
| 点击此处可从《实用肝脏病杂志》浏览原始摘要信息 |
|
点击此处可从《实用肝脏病杂志》下载免费的PDF全文 |
|
