| 结直肠癌组织MSI状态及其与临床病理参数之间的相关性 |
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| 引用本文： | 郑 超,王玻玮,才 层,穆艾太尔·麦提努日,马方婧.结直肠癌组织MSI状态及其与临床病理参数之间的相关性[J].现代肿瘤医学,2021,0(17):3053-3056. |
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| 作者姓名： | 郑 超 王玻玮 才 层 穆艾太尔·麦提努日 马方婧 |
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| 作者单位： | 1.新疆医科大学第一附属医院肿瘤中心;2.病理科;3.乳腺外科，新疆 乌鲁木齐 830054 |
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| 基金项目： | 新疆维吾尔自治区自然科学基金（编号:2017D01C303） |
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| 摘 要： | 目的:分析结直肠癌组织微卫星不稳定（MSI）状态及其与临床病理参数之间的相关性。方法:利用免疫组化法检测MLH1、MSH2、MSH6、PMS2错配修复蛋白的表达，分析441例结直肠癌组织的MSI状态。结果:免疫组化检测发现，441例结直肠癌中，微卫星稳定（MSS）为375例，MLH1、MSH2、MSH6、PMS2错配修复蛋白任一表达缺失共66例，占14.97%（66/441）;其中MLH1、MSH2、MSH6、PMS2单一表达缺失率分别为1.4%（6/441）、0.2%（1/441）、0.7%（3/441）、2.3%（10/441）;MLH1和PMS2同时表达缺失率9.1%（40/441），MSH2和MSH6同时表达缺失率1.1%（5/441），MSH6和PMS2同时表达缺失率0.2%（1/441）。结直肠癌患者MSI与MSS在民族、肿瘤部位、分化程度、T分期、N分期、肿瘤大小等临床病理特征方面存在差异，而在性别、年龄、大体类型、病理类型、M分期、临床分期、神经和脉管侵犯方面均无明显差异。结论:新疆少数民族、右半结肠、低分化、T4、N0、肿瘤＞5 cm的结直肠癌患者更易发生MSI。
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| 关 键 词： | 结直肠肿瘤 DNA错配修复蛋白 微卫星不稳定 免疫组织化学 |
Correlation between MSI status and clinicopathologic features in colorectal cancer tissue |
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| ZHENG Chao,WANG Bowei,CAI Ceng,Muattar·Matnuri,MA Fangjing.Correlation between MSI status and clinicopathologic features in colorectal cancer tissue[J].Journal of Modern Oncology,2021,0(17):3053-3056. |
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| Authors: | ZHENG Chao WANG Bowei CAI Ceng Muattar·Matnuri MA Fangjing |
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| Affiliation: | 1.Department of Oncology;2.Department of Pathology;3.Department of Breast Surgery，the First Affiliated Hospital of Xinjiang Medical University，Xinjiang Urumqi 830054，China． |
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| Abstract: | Objective:To analyze the MSI status in the colorectal cancer (CRC) and to explore the correlation with clinicopathological charateristics.Methods:Immunohistochemical staining was used to detect the expression of DNA mismatch repair proteins (MLH1，MSH2，MSH6 and PMS2) from 441 CRC patients.Results:Immunohistochemisty showed that MSS was 375 of 441 cases of colorectal cancer.Sixty-six cases of 441 cases (14.97%) lost at least one MMR protein expression.Expression deficiency rates of MLH1,MSH2,MSH6 and PMS2 were 1.4%（6/441）,0.2%（1/441）,0.7%（3/441）,and 2.3%（10/441）,respectively.MMR expression deficiency mainly consisted of combined loss of MLH1/PMS2 (9.1%,40/441)，MSH2/MSH6 (1.1%,5/441)，and MSH6/PMS2 (0.2%,1/441).There are differences between the MSI and MSS by CRC patients with race,tumor location,tumor differentiation degree,T stage,N stage,and tumor size(P＜0.05),but had no obvious differences in gender,age,tumor gross type,pathological type,M stage,clinical stage,nerve invasion and vascular invasion.Conclusion:The CRC patients with Xinjiang minorities,right hemicolon,poorly differentiated,T4,N0,tumor size (＞5 cm) are more likely to divelop MSI. |
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| Keywords: | colorectal neoplasms DNA mismatch repair microsatellite instability immunohistochemistry |
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