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| 非小细胞肺癌发生骨转移的危险因素分析 | |
| 引用本文： | 王海玉1,李 波2,许小飞2,童金龙1,魏晨晨3,葛小林4. 非小细胞肺癌发生骨转移的危险因素分析[J]. 现代肿瘤医学, 2021, 0(13): 2274-2278. DOI: 10.3969/j.issn.1672-4992.2021.13.015 |
| 作者姓名： | 王海玉1 李 波2 许小飞2 童金龙1 魏晨晨3 葛小林4 |
| 作者单位： | 1.南京中医药大学附属南京医院（南京市第二医院）放射治疗科，江苏 南京 210003；2.南京医科大学第二附属医院核医学科；3.肿瘤医学中心，江苏 南京 210011；4.江苏省人民医院（南京医科大学第一附属医院）放射治疗科，江苏 南京 210029 |
| 基金项目： | National Natural Science Foundation of China（No.81703056）;国家自然科学基金资助项目（编号:81703056）；南京医科大学科技发展基金（编号:NMUB2018053） |
| 摘 要： | 目的:探讨影响非小细胞肺癌骨转移的危险因素。方法:选取2015年至2019年在南京医科大学第二附属医院住院治疗的非小细胞肺癌患者207例［骨转移组（n=113）、无骨转移组（n=94）］。检测血清CA125、CEA、NSE、CYFRA21-1、LDH和ALP的水平，记录年龄、性别、吸烟史、高血压、糖尿病、临床分期、肿瘤位置、组织学类型和淋巴结转移等因素。采用单因素和Logistic多因素回归分析筛选影响非小细胞肺癌患者骨转移的危险因素。结果:单因素分析结果发现两组临床分期、淋巴结转移、CA125、CEA、NSE、CYFRA21-1、LDH比较具有统计学差异（P＜0.05）；NSE、CYFRA21-1在腺癌和鳞状细胞癌血清中水平无统计学差异（P＞0.05）；Logistic多因素回归分析结果显示，临床分期、淋巴结转移和CA125是影响非小细胞肺癌患者骨转移的主要因素（P＜0.01）。结论:临床分期、淋巴结转移和CA125是影响非小细胞肺癌患者骨转移的独立危险因素，为临床早期治疗提供重要的指导意义。 |
| 关 键 词： | 非小细胞肺癌 骨转移 危险因素 |
Analysis of risk factors influencing the bone metastasis of non-small cell lung cancer |
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| WANG Haiyu1,LI Bo2,XU Xiaofei2,TONG Jinlong1,WEI Chenchen3,GE Xiaolin4. Analysis of risk factors influencing the bone metastasis of non-small cell lung cancer[J]. Journal of Modern Oncology, 2021, 0(13): 2274-2278. DOI: 10.3969/j.issn.1672-4992.2021.13.015 | |
| Authors: | WANG Haiyu1 LI Bo2 XU Xiaofei2 TONG Jinlong1 WEI Chenchen3 GE Xiaolin4 |
| Affiliation: | 1.Department of Radiation Oncology,Second Hospital of Nanjing,Nanjing Hospital Affiliated to Nanjing University of Chinese Medicine,Jiangsu Nanjing 210003,China;2.Department of Nuclear Medicine;3.Cancer Medical Center,the Second Affiliated Hospital of Nanjing Medical University,Jiangsu Nanjing 210011,China;4.Department of Radiation Oncology,Jiangsu Province Hospital,the First Affiliated Hospital of Nanjing Medical University,Jiangsu Nanjing 210029,China. |
| Abstract: | Objective:To clarify the risk factor for bone metastasis （BM） with non-small cell lung cancer.Methods:A total of 207 patients with non-small cell lung cancer (NSCLC),obtained from the Second Affiliated Hospital of Nanjing Medical University during the period of 2015 to 2019,were enrolled in this study ［bone metastasis group (n=113),non-bone metastasis group (n=94)］.The levels of cancer antigen 125 (CA125),carcinoembryonic antigen (CEA),cytokeratin-19 fragment (CYFRA21-1),neuron specific enolase (NSE),alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) were measured.Information about NSCLC patients such as age,gender,smoking history,hypertension,diabetes,histopathological type,clinical stage,tumor location and lymph node metastasis was collected from medical records.Univariate and multivariate Logistic regression were used to evaluate the association between risk factors and bone metastasis.Results:There was a statistically significant difference in CA125,CEA,CYFRA21-1,NSE,LDH,clinical stage and lymph node metastasis between two groups (P＜0.05).The levels of serum NSE and CYFRA21-1 in adenocarcinoma and squamous cell carcinoma was not statistically different (P＞0.05).Multivariate Logistic regression analysis showed that the factors associated with bone metastasis were CA125,clinical stage and lymph node metastasis (P＜0.01).Conclusion:CA125,clinical stage and lymph node metastasis were risk factors that affect the bone metastasis of NSCLC and provide important guiding significance for clinical prevention and treatment. |
| Keywords: | non-small cell lung cancer bone metastasis risk factors |
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