| 中期18F-FDG PET/CT检查对评估R-CHOP治疗弥漫性大B细胞淋巴瘤疗效和预后的价值 |
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| 引用本文： | 苏洁敏,郑庆中,黄文荣,邓 菁,吴 军.中期18F-FDG PET/CT检查对评估R-CHOP治疗弥漫性大B细胞淋巴瘤疗效和预后的价值[J].现代肿瘤医学,2021,0(19):3453-3457. |
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| 作者姓名： | 苏洁敏 郑庆中 黄文荣 邓 菁 吴 军 |
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| 作者单位： | 海南西部中心医院，海南 儋州 571799 |
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| 基金项目： | 海南省医学科研基金资助(编号:17A200824) |
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| 摘 要： | 目的:探讨18F-氟代脱氧葡萄糖正电子发射型计算机断层显像/计算机体层成像（18F-FDG PET/CT）检查对弥漫大B细胞淋巴瘤（DLBCL）预后评估的价值。方法:分析治疗前及治疗中期接受18F-FDG PET/CT检查并经病理确诊的62例DLBCL患者的临床资料，通过Deauville评分、最大标准摄取值减少率（△SUVmax）及国际预后指数（IPI）分析患者的疗效。采用Kaplan-Meier法、Log-rank检验及多因素COX回归分析Deauville评分、△SUVmax及IPI评分与无进展生存时间(PFS)和总生存时间（OS）的关系。结果:62例患者随访时间为14～59个月，中位随访时间为42个月。受试者工作特征（ROC）曲线计算△SUVmax最佳分界点为64.2％，Deauville评分、△SUVmax评估DLBCL患者的敏感度和特异度分别为76.2%和65.0%、90.5%和75.0%。Deauville评分评估DLBCL患者疗效的准确度为85.5％，高于△SUVmax（72.6%）。生存曲线分析显示，Deauville评分4～5分、△SUVmax<64.2％及IPI评分3～5分与DLBCL患者PFS和OS低有关（P＜0.001）。多因素COX回归分析显示，Deauville评［HR（95%CI）=3.740（1.725～7.662）］分/［HR（95%CI）=2.850（1.647～6.314）］及IPI评分［HR（95%CI）=2.624（1.380～5.927）］/［HR（95%CI）=2.372（1.128～5.190）］是影响DLBCL患者PFS和OS的独立危险因素（P＜0.05）。结论:中期PET/CT显像对评估DLBCL患者的疗效及预后具有较好的价值。
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| 关 键 词： | 弥漫大B细胞淋巴瘤 正电子发射型计算机断层显像/计算机体层成像 18F-氟代脱氧葡萄糖 疗效 预后 |
The value of medium-term 18F-FDG PET/CT examination in evaluating the efficacy and prognosis of R-CHOP in the treatment of diffuse large B cell lymphoma |
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| SU Jiemin,ZHENG Qingzhong,HUANG Wenrong,DENG Jing,WU Jun.The value of medium-term 18F-FDG PET/CT examination in evaluating the efficacy and prognosis of R-CHOP in the treatment of diffuse large B cell lymphoma[J].Journal of Modern Oncology,2021,0(19):3453-3457. |
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| Authors: | SU Jiemin ZHENG Qingzhong HUANG Wenrong DENG Jing WU Jun |
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| Affiliation: | Department of Radiology，Hainan West Central Hospital，Hainan Danzhou 571799，China. |
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| Abstract: | Objective:To evaluate the prognostic value of medium-term 18F-FDG PET/CT for diffuse large B-cell lymphoma(DLBCL).Methods:The clinical data of 62 patients with DLBCL who were examined by 18F-FDG PET/CT before treatment and in middle stage the treatment were analyzed.The Deauville score,maximum standard uptake reduction rate(△SUVmax)and international prognostic index(IPI)were used to analyze the outcome of the patients.Kaplan-Meier method,log rank test and multivariate Cox regression were used to analyze the relationship between Deauville score,△SUVmax and IPI score and PFS and OS.Results:The follow-up time of 62 patients was 14~59 months,and the median follow-up time was 42 months.The best cut-off point of △SUVmax calculated by ROC curve was 64.2%.The sensitivity and specificity of Deauville score,△SUVmax in DLBCL patients were 76.2% and 65.0%,90.5% and 75.0%,respectively.The accuracy of the Deauville score in evaluating the efficacy of DLBCL patients was 85.5%,higher than the △SUVmax(72.6%).The survival curve analysis showed that Deauville score 4~5,△SUVmax<64.2％ and IPI score 3~5 were related to low PFS and OS in DLBCL patients(P＜0.01).Multivariate Cox regression analysis showed that Deauville score［HR（95%CI）=3.740（1.725～7.662）］/［HR（95%CI）=2.850（1.647～6.314）］and about IPI score［HR（95%CI）=2.624（1.380～5.927）］/［HR（95%CI）=2.372（1.128～5.190）］were independent risk factors for PFS and OS in DLBCL patients(P＜0.05).Conclusion:The mid-term PET/CT imaging has a good value in evaluating the curative effect and prognosis of DLBCL patients. |
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| Keywords: | diffuse large B cell lymphoma positron emission computed tomography/computed tomography 18F-fluorodeoxyglucose curative effect prognosis |
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