| CK15及CK19在表皮及皮肤附属器肿瘤中的表达及其诊断价值 |
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| 引用本文： | 周晓秋,燕丽,李红静,李青,孙希印,王东关,李新功. CK15及CK19在表皮及皮肤附属器肿瘤中的表达及其诊断价值[J]. 现代肿瘤医学, 2021, 0(20): 3628-3631. DOI: 10.3969/j.issn.1672-4992.2021.20.025 |
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| 作者姓名： | 周晓秋 燕丽 李红静 李青 孙希印 王东关 李新功 |
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| 作者单位： | 东营市人民医院病理科,山东 东营 257091 |
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| 基金项目： | 山东省医药卫生科技发展计划项目（编号:2016WS0085） |
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| 摘 要： | 目的:检测表皮干细胞标记物细胞角蛋白15(CK15)及细胞角蛋白19(CK19)在表皮肿瘤及皮肤附属器肿瘤中的表达强度.方法:选择155例东营市人民医院病理科确诊的皮肤肿瘤,进行免疫组织化学检测,观察并记录CK15和CK19的表达强度.结果:155例皮肤肿瘤组织中CK15和CK19的表达强度不同.CK15毛分化肿瘤均显...
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| 关 键 词： | 表皮干细胞 皮肤肿瘤 细胞角蛋白 病理性 免疫组织化学 |
The expression and diagnostic value of CK15 and CK19 in epidermal and skin adnexal tumors |
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| ZHOU Xiaoqiu,YAN Li,LI Hongjing,LI Qing,SUN Xiyin,WANG Dongguan,LI Xingong. The expression and diagnostic value of CK15 and CK19 in epidermal and skin adnexal tumors[J]. Journal of Modern Oncology, 2021, 0(20): 3628-3631. DOI: 10.3969/j.issn.1672-4992.2021.20.025 |
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| Authors: | ZHOU Xiaoqiu YAN Li LI Hongjing LI Qing SUN Xiyin WANG Dongguan LI Xingong |
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| Affiliation: | Department of Pathology,Dongying People's Hospital,Shandong Dongying 257091,China. |
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| Abstract: | Objective:To detect the expression levels of epidermal stem cell markers CK15 and CK19 in epidermal tumors and skin appendage tumors.Methods:A total of 155 cases of skin tumors confirmed by the Pathology Department of Dongying People's Hospital were selected for immunohistochemical detection,and the expression levels of cytokeratins 15 and 19 were observed and recorded.Results:The expression levels of CK15 and CK19 were different in 155 skin tumors.Hair differentiated tumors showed positive expression of CK15,and the expression of tricholemmoma/tricholemmal carcinoma was significantly different from that of squamous cell carcinomas（P＜0.05).There were significant differences in the expression between trichoblastoma and similar histomorphology skin tumors,such as basal cell carcinoma and poroma（P＜0.05).CK19 was almost not expressed in squamous cell carcinoma,tricholemmoma/tricholemmal carcinoma,and was significantly different from basal cell carcinoma,sweat gland-derived tumor and hair follicle tumor（P＜0.05).Conclusion:The expression levels of CK15 and CK19 detected by immunohistochemistry can be used for the diagnosis and differential diagnosis of skin tumors with similar histomorphology. |
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| Keywords: | epidermal stem cells skin neoplasms cytokeratin pathology immunohistochemistry |
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