| 精神分裂症患者肠道菌群与临床症状的相关性研究 |
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| 引用本文： | 王中娴,张爱国,姚理慧,程夏龙,程鹏,朱翠珍,苏虹,张许来. 精神分裂症患者肠道菌群与临床症状的相关性研究[J]. 中华全科医学, 2021, 19(9): 1530-1534. DOI: 10.16766/j.cnki.issn.1674-4152.002104 |
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| 作者姓名： | 王中娴 张爱国 姚理慧 程夏龙 程鹏 朱翠珍 苏虹 张许来 |
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| 作者单位： | 1.安徽省精神卫生中心,安徽 合肥 230022 |
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| 基金项目： | 国家自然科学基金项目81773518合肥市科技局“借转补”项目J2018Y05 |
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| 摘 要： | 目的 探究精神分裂症菌群结构特征与临床症状的相关性.方法 纳入2018年10月-2019年6月合肥市第四人民医院收治的精神分裂症患者急性发作期(A组)32例,缓解期(B组)30例,健康对照(C组)34人.运用16SrRNA技术分析菌群差异及与临床症状的相关性.结果 (1)另枝菌属A组丰度高于C组(F=2.575,P=0...
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| 关 键 词： | 精神分裂症 肠道菌群 高通量测序 临床症状 |
| 收稿时间： | 2020-06-15 |
Correlation between intestinal flora and clinical symptoms in patients with schizophrenia |
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| Affiliation: | Anhui Metal Health Center, Hefei, Anhui 230022, China |
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| Abstract: | Objective This study aimed to explore the correlation between the structural characteristics of schizophrenia flora and clinical symptoms. Methods Patients who were diagnosed with schizophrenia in the fourth hospital in Hefei from October 2018 to June 2019 were included in this study: 32 patients in the acute stage (group A), 30 in the remission stage (group B) and 34 in the healthy control group (group C). The 16SrRNA technique was used to analyse the difference of bacterial flora and its correlation with clinical symptoms. Results (1) The abundance of other mycobacteria in group A was higher than that in group C (F=2.575, P=0.017), whereas the abundance of thiobacillus in group A was lower than that in group C (F=3.940, P=0.023). The abundance of macrococcidia in groups A and B was higher than that of group C (F=11.720, P < 0.001), and the abundance of trichoderma and coprococcus in groups A and B was lower than that of group C (F=4.279、3.670, all P < 0.05). The abundance of Bacteroidetes, haemophilus and Clostridium tyrosine in group A was higher than that in group B (F=2.977, 4.840; F=2.655, P < 0.05), and the abundance of vibrio succinate was lower than that of group B (F=6.190, P=0.003). (2) Microbacilli were negatively correlated with depression factors (r=-0.269, P=0.034). Macrosomonas was positively correlated with the total PANSS score (r=0.291, P=0.022). Bacteroidetes was positively correlated with positive factors (r=0.282, P=0.029). Conclusion The structural changes of the microflora in the acute and remission stages of schizophrenia and the relative abundance of some microflora were correlated with clinical symptoms. |
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