| 非增生期糖尿病视网膜病变患者黄斑区血流密度变化:基于OCTA的定量分析 |
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| 引用本文： | 李海东,方伟,吴素兰,廉恒丽,徐小琼,董思思,沈丽君. 非增生期糖尿病视网膜病变患者黄斑区血流密度变化:基于OCTA的定量分析[J]. 眼科新进展, 2021, 0(2): 170-173. DOI: 10.13389/j.cnki.rao.2021.0036 |
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| 作者姓名： | 李海东 方伟 吴素兰 廉恒丽 徐小琼 董思思 沈丽君 |
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| 作者单位： | 310020 浙江省杭州市，温州医科大学附属眼视光医院杭州院区 |
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| 摘 要： | 目的 应用光学相干断层扫描血管成像(OCTA)定量分析非增生期糖尿病视网膜病变(NPDR)患者黄斑区视网膜血流密度(retinal vessel density,RVD)的改变.方法 回顾性横断面观察性研究.纳入2019 年1 月至12 月在温州医科大学附属眼视光医院杭州院区就诊的2 型糖尿病且伴NPDR 的患者28 ...
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| 关 键 词： | 糖尿病视网膜病变 黄斑 血流密度 光学相干断层扫描血管成像 |
Quantitative analysis of macular vessel density changes in non-proliferative diabetic retinopathy through optical coherence tomography angiography |
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| LI Haidong,FANG Wei,WU Sulan,LIAN Hengli,XU Xiaoqiong,DONG Sisi,SHEN Lijun. Quantitative analysis of macular vessel density changes in non-proliferative diabetic retinopathy through optical coherence tomography angiography[J]. Recent Advances in Ophthalmology, 2021, 0(2): 170-173. DOI: 10.13389/j.cnki.rao.2021.0036 |
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| Authors: | LI Haidong FANG Wei WU Sulan LIAN Hengli XU Xiaoqiong DONG Sisi SHEN Lijun |
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| Affiliation: | Hangzhou Branch of Eye Hospital,Wenzhou Medical University,Hangzhou 310020,Zhejiang Province,China |
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| Abstract: | Objective To investigate quantitative changes of macular retinal vessel density (RVD) in non-proliferative diabetic retinopathy (NPDR) through optical coherence tomography angiography (OCTA). Methods A retrospective cross-sectional observational study. From January to December 2019, twenty-eight patients (45 eyes) with NPDR from Type 2 diabetes mellitus (NPDR group) and 20 individuals (40 eyes) of age and sex matched healthy subjects (control group) in Hangzhou Branch of Eye Hospital of Wenzhou Medical University were included in the study. Automated OCTA/split-spectrum amplitude decorrelation angiography was applied in all eyes. A 3 mm×3 mm scan centered on the fovea was obtained, and the RVDs of superficial and deep retinal plexuses in parafoveal (central 1-3 mm) zone were analyzed.Results Compared with the control group, the average parafoveal superficial and deep RVD of NPDR group decreased by 6.47% ［(43.54±4.43)%,(46.55±4.13)%］ and 6.06% ［(45.62±5.87)%,(48.56±5.31)%］ respectively, and both differences were statistically significant (all P<0.05). The superficial RVDs in all quadrants of the NPDR group were lower than those of the normal control group ［temporal (42.34±4.40)%, (46.06±3.85)%, superior (44.33±5.57)%, (47.92±4.26)%, nasal (42.96±4.50)%, (45.50±4.31)%, inferior (44.58±4.45)%, (46.88±4.94)%, respectively, all P＜0.05)］. Furthermore, the temporal quadrant had the largest vessel density reduction (8.07%). Similarly, the deep RVDs of all quadrants of the NPDR group were lower than their counterparts, and except that the difference in the superior quadrant was not statistically significant ［(45.43±6.30)%, (47.82±5.54)%, P=0.068］, the difference in the other quadrants was statistically significant ［temporal (45.84±5.71)%, (49.54±4.86)%, nasal (46.53±5.91)%, (49.45±5.29)%, inferior (44.62±6.64)%, (47.43±5.91)%, respectively, all P＜0.05］. The temporal area also had the largest vessel density reduction (7.48%).Conclusion The macular superficial and deep retinal capillary layers are damaged in the patients with NPDR, especially in the temporal part. |
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| Keywords: | diabetic retinopathy macula vessel density optic coherence tomography angiography |
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