| 基于Oncomine和Kaplan-Meier Plotter数据库分析GPX2在非小细胞肺癌组织中的表达和临床意义 |
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| 引用本文： | 高 华,张贝贝,庞俊芳,王 黎.基于Oncomine和Kaplan-Meier Plotter数据库分析GPX2在非小细胞肺癌组织中的表达和临床意义[J].现代肿瘤医学,2021,0(19):3390-3395. |
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| 作者姓名： | 高 华 张贝贝 庞俊芳 王 黎 |
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| 作者单位： | 河南省省立医院肿瘤科，河南 郑州 450019 |
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| 摘 要： | 目的:探讨谷胱甘肽过氧化物酶2（glutathione peroxidase 2，GPX2）在非小细胞肺癌组织中的表达及预后意义。方法:基于Oncomine和Kaplan-Meier Plotter数据库，收集关于GPX2表达的相关数据集,深入挖掘GPX2在非小细胞肺癌组织与正常组织中的差异表达情况。采用Kaplan-Meier法进行预后分析,并绘制生存曲线。此外，通过单/多因素COX回归进一步评估GPX2在不同临床特征中的预后评估价值。结果:与正常组织相比，GPX2在非小细胞肺癌组织中高表达（P＜0.001）。 GPX2高表达非小细胞肺癌患者的总体生存率（HR=1.42,95%CI:1.25~1.61,P=5.6E-08）和肺腺癌患者的总体生存率（HR=1.35,95%CI:1.07~1.71,P=0.011）均差于低表达组。但GPX2表达水平对鳞癌患者预后无显著影响（HR=1.06,95%CI:0.84~1.35,P=0.61）。此外，本研究也发现GPX2的表达对同一临床特征（如男性、临床分期、吸烟/不吸烟、经化疗方式治疗）的患者的预后有预测评估价值。多因素分析结果显示临床分期和GPX2的表达是非小细胞肺癌患者预后的独立影响因素。结论:检测非小细胞肺癌组织中GPX2的表达有助于患者预后评估。
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| 关 键 词： | NSCLC GPX2 Oncomine数据库 Kaplan-Meier Plotter数据库 |
Expression of GPX2 in non-small cell lung cancer tissues and its clinical significance based on the Oncomine and Kaplan-Meier Plotter databases |
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| GAO Hua,ZHANG Beibei,PANG Junfang,WANG Li.Expression of GPX2 in non-small cell lung cancer tissues and its clinical significance based on the Oncomine and Kaplan-Meier Plotter databases[J].Journal of Modern Oncology,2021,0(19):3390-3395. |
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| Authors: | GAO Hua ZHANG Beibei PANG Junfang WANG Li |
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| Affiliation: | Department of Oncology，Henan Provincial Hospital，Henan Zhengzhou 450019,China. |
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| Abstract: | Objective:To explore the expression of glutathione peroxidase 2（GPX2） and its prognostic significance in NSCLC.Methods:Based on the Oncomine and Kaplan-Meier Plotter databases,the data sets of GPX2 gene expression were collected to further explore the differential expression of GPX2 in non-small cell lung cancer tissues and normal tissues.Prognostic analysis was performed using the Kaplan-Meier method and the survival curves were plotted.Furthermore,the prognostic value of GPX2 in different clinical features was further evaluated by single/multivariate COX regression.Results:GPX2 was highly expressed in lung cancer tissues compared to normal tissues（P＜ 0.001）.The overall survival rate of patients with high GPX2 expression of lung cancer（HR=1.42,95%CI:1.25~1.61,P=5.6E-08）and lung adenocarcinoma（HR=1.35,95%CI:1.07~1.71,P=0.011）was worse than that of the low expression group.However,the expression level of GPX2 had no significant effect on the prognosis of patients with squamous cell carcinoma（HR=1.06,95%CI:0.84~1.35,P=0.61）.In addition,this study also found that the expression of GPX2 had an appreciative value for the prognosis of patients with the same clinical features(such as male,clinical staging,smoking/non-smoking,and chemotherapy).Multivariate analysis showed that clinical stage and GPX2 expression were independent prognostic factors for patients with non-small cell lung cancer.Conclusion:GPX2 is highly expressed in NSCLC and associated with poor prognosis,which may be a new target for the development of lung cancer or a potential biomarker for the prognosis. |
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| Keywords: | NSCLC GPX2 Oncomine database Kaplan-Meier Plotter database |
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