Endosomal compartment: Also a dock for MHC class I peptide loading |
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| Authors: | Wenbin Ma Benoît J. Van den Eynde |
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| Affiliation: | Ludwig Institute for Cancer Research, de Duve Institute, WELBIO (Walloon Excellence in Life Sciences and Biotechnology), Université catholique de Louvain, Brussels, Belgium |
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| Abstract: | ![]()
The endosomal compartment, which contains all the components required for loading peptides onto MHC class II molecules, is classically considered to be dedicated to the loading of MHC class II but not MHC class I molecules. However, a report in this issue of the European Journal of Immunology [Eur. J. Immunol. 2014. 44: 774–784], together with other recent studies, shows that the endosomal compartment also supports efficient loading of MHC class I molecules. These results bring a new perspective on the crosstalk between the MHC class II and MHC class I antigen‐processing pathways, and may inspire new ideas for the design of vaccines against viruses and tumors. |
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| Keywords: | Antigen presentation/processing CD8+ T cells MHC Vaccination |
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