| 维吾尔族烟雾病病人血清miRNA的异常表达及其基因分析 |
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| 引用本文： | 李海蒙,周广平,水,政,俞,辉,孙育海,洪,波.维吾尔族烟雾病病人血清miRNA的异常表达及其基因分析[J].中国临床神经外科杂志,2021,26(1):32-34. |
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| 作者姓名： | 李海蒙 周广平 水 政 俞 辉 孙育海 洪 波 |
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| 作者单位： | 844710 新疆，莎车县人民医院神经外科（李海蒙、周广平、水 政）；200433 上海，海军军医大学附属长海医院神经外科（李海蒙、洪 波）；201318，上海浦东新区周浦医院神经外科（俞 辉、孙育海） |
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| 摘 要： | 目的 探讨我国新疆地区维吾尔族（简称维族）烟雾病病人血清异常表达的miRNA。方法 收集2017年2月至2018年8月新疆莎车县人民医院救治的8例维族烟雾病与8例维族健康者（对照组）的血样，运用高通量全基因芯片技术检测血清miRNA，筛选差异表达水平大于1.5倍的miRNA，然后利用targetscan软件进行靶基因的预测和分析。结果 发现54个差异表达的miRNA，选择表达水平变化倍数R在0.67~1.5的差异表达miRNA共4个，其中显著上调3个（miR-188-5p、miR-4284及miR-5100），显著下调1个（miR-6277-3p）。靶基因生物学分析结果显示维吾尔族烟雾病可能与某类锌指蛋白有关。结论 维族烟雾病病人血清miRNA有异常表达，通过生物信息学分析，其致病基因可能某类锌指蛋白有关。
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| 关 键 词： | 烟雾病 miRNA 维吾尔族 基因表达 |
Abnormal expression of serum miRNA in Uygur patients with moyamoya disease |
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| LI Hai-meng,,ZHOU Guang-ping,SHUI Zheng,YU Hui,SUN Yu-hai,HONG Bo..Abnormal expression of serum miRNA in Uygur patients with moyamoya disease[J].Chinese Journal of Clinical Neurosurgery,2021,26(1):32-34. |
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| Authors: | LI Hai-meng ZHOU Guang-ping SHUI Zheng YU Hui SUN Yu-hai HONG Bo |
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| Affiliation: | 1. Department of Neurosurgery, Shache People’s Hospital, Xinjiang Uygur Autonomous Region, Shache 844710, China; 2. Department of Neurosurgery, Changhai Hospital, Naval Medical University, PLA, Shanghai 200433, China; 3. Department of Neurosurgery, Zhoupu |
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| Abstract: | Objective To analyze the abnormal expression of serum miRNA in Uyghur patients with moyamoya disease in Xinjiang Uygur Autonomous Region, China. Methods The serum miRNAs of 8 Uyghur patients with moyamoya disease who were treated in Shache People’s Hospital from February 2017 to August 2018 and of 8 health Uyghur people by high-throughput whole-genome technology. The miRNAs with differential expression levels greater than 1.5 times were screened for target gene prediction and analysis using targetscan software. Rusults A total of 54 differentially expressed miRNAs was selected. A change in expression level R between 0.67 and 1.5 was found in 4 differentially expressed miRNAs, of which 3 miRNAs were significantly up-regulated (miR-188-5p, miR-4284 and miR-5100), and 1 was significantly down-regulated (miR-6277-3p). The biological analysis of target genes showed that Uyghur patients with moyamoya disease may be related to a certain type of zinc finger protein. Conclusions There are abnormal expressions of miRNA in the serum of Uyghur patients with moyamoya disease. The bioinformatics analysis results suggest that the pathogenic genes may be related to a certain type of zinc finger protein. |
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| Keywords: | Moyamoya disease MicroRNA Uyghur patients Xinjiang Uygur Autonomous Region |
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