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Cancer stem cell mediated acquired chemoresistance in head and neck cancer can be abrogated by aldehyde dehydrogenase 1 A1 inhibition
Authors:Safeena Kulsum  Holalugunda Vittalamurthy Sudheendra  Ramanan Pandian  Doddathimmasandra Ramanjanappa Ravindra  Gangotri Siddappa  Nisheena R  Priyanka Chevour  Balaji Ramachandran  Milind Sagar  Aravindakshan Jayaprakash  Alka Mehta  Vikram Kekatpure  Naveen Hedne  Moni A. Kuriakose  Amritha Suresh
Affiliation:1. Integrated Head and Neck Oncology Research Program, Mazumdar Shaw Centre for Translational Research, Mazumdar Shaw Medical Centre, Narayana Health, Bommasandra, Anekal Taluk Bangalore, Karnataka, India;2. School of Biosciences and Technology, VIT University, Vellore, Tamil Nadu, India;3. GROW Laboratory;4. Narayana Nethralaya Foundation, Narayana Health, Bangalore, Karnataka, India;5. Head and Neck Oncology, Mazumdar Shaw Medical Centre, Narayana Health, Bommasandra, Anekal Taluk Bangalore, Karnataka, India;6. Department of Pathology, Mazumdar Shaw Medical Centre, Narayana Health, Bommasandra, Anekal Taluk Bangalore, Karnataka, India;7. Department of In Vivo Pharmacology‐Oncology, Syngene International Pvt. Ltd., Bangalore, India;8. Mazumdar Shaw Medical Centre‐Roswell Park Collaboration Program, Roswell Park Cancer Institute, Buffalo, New York
Abstract:
Keywords:drug resistant cell lines  cross resistance  ALDH1A1  head and neck cancer  cancer stem cells
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