| 三维动脉自旋标记在单侧颈内动脉闭塞后侧支循环评估中的价值 |
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| 作者姓名： | 周建国 符大勇 卢明聪 孟云 李士坤 刘晓丽 |
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| 作者单位： | 1.南京中医药大学连云港附属医院 放射科2.南京中医药大学连云港附属医院 康复科，江苏 连云港 222004 |
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| 基金项目： | 连云港市卫生健康委面上科研项目(201921);南京医科大学康达学院2018年度科研发展基金课题(KD2018KYJJYB027)。 |
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| 摘 要： | 目的探讨三维动脉自旋标记（3D ASL）技术在评估单侧颈内动脉闭塞后侧支循环建立状态方面的临床应用价值。方法收集2018年1月~2020年2月经三维时间飞跃法磁共振血管成像提示单侧颈内动脉闭塞且无其他颅内动脉中重度狭窄患者22例，其中男13例，女9例，年龄35~76岁（52.2±15.5岁），均行3D ASL序列灌注成像检查，使用Functool软件将原始数据自动生成脑血流量（CBF）伪彩图，分别于闭塞侧颈内动脉供血区及镜像区额叶、顶叶、脑室旁白质区、基底节区选取感兴趣区（ROI=200±20 mm2），并对比责任颈内动脉供血区与镜像区不同标记后延迟(PLD)时间脑血流量值差异。结果入组患者中，左侧颈内动脉闭塞12例，右侧颈内动脉闭塞10例，3D ASL（PLD:1 525 ms）时闭塞颈内动脉供血区脑血流量值明显低于镜像区，两组差异有统计学意义（P<0.05），当PLD为2 525 ms时，闭塞颈内动脉供血区脑血流量值略低于镜像区，但差异无明显统计学意义（P>0.05）。结论3D ASL成像技术可用于评估单侧颈内动脉闭塞后侧支循环建立及灌注状态，对于患者治疗方案的选择及预测临床预后均具有重要价值。
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| 关 键 词： | 颈内动脉 侧支循环 动脉自旋标记 脑血流量 |
| 收稿时间： | 2020-02-12 |
Clinical application of 3D ASL in assessment of collateral circulation after unilateral internal carotid artery occlusion |
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| Authors: | ZHOU Jianguo FU Dayong LU Mingcong MENG Yun LI Shikun LIU Xiaoli |
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| Affiliation: | 1.Department of Radiology2.Department of Rehabilitation, Nanjing University of Chinese Medicine Affiliated Lianyungang Hospital, Lianyungang 222004, China |
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| Abstract: | Objective To evaluate the clinical value of 3 D ASL in the assessment of collateral circulation after unilateral internal carotid artery(ICA) occlusion. Methods From January 2018 to February 2020, 22 patients with unilateral ICA occlusion and no other moderate or severe stenosis of intracranial artery were studied by 3 D-TOF MRA In ASL sequence perfusion imaging,including 13 males and 9 females with the age from 35 to 76(average 52.2±15.5). The functool software was used to automatically generate the pseudocolor image of cerebral blood flow(CBF) from the original data. The areas of interest(ROI=200±20 mm2) were selected from the blood supply area of ICA on the occluded side and the frontal lobe, parietal lobe,paraventricular white matter area and basal ganglia area of the mirror image area. The CBF values of the time delay(PLD)between the responsible ICA blood supply area and the mirror image area were compared. Results There were 12 cases of ICA occlusion on the left side and 10 cases of ICA occlusion on the right side. The CBF value in the blood supply area of ICA occlusion was significantly lower than that in the mirror area in 3 D ASL(PLD: 1 525 ms). The difference between the two groups was significant(P<0.05). When PLD was 2 525 ms, the CBF value in the blood supply area of ICA occlusion was slightly lower than that in the mirror area, but the difference was not significant(P>0.05). Conclusion 3 D ASL imaging technology can be used to evaluate the establishment of collateral circulation and perfusion state after unilateral ICA occlusion, which is of great value for the selection of treatment plan and the prediction of clinical prognosis. |
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| Keywords: | internal carotid artery collateral pathway arterial spin labeling cerebral blood flow |
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