Bowel necrosis induced by tumor necrosis factor in rats is mediated by platelet-activating factor. |
| |
| Authors: | X M Sun and W Hsueh |
| |
| Affiliation: | Department of Pathology, Children's Memorial Hospital, Northwestern University, Chicago, Illinois 60614. |
| |
| Abstract: | We have developed a rat model of ischemic bowel necrosis associated with shock by injection of platelet-activating factor (PAF) or a combination of PAF and endotoxin. Recent investigations have shown that tumor necrosis factor (TNF) also induces shock and necrosis of the gastrointestinal tract. The morphological changes of TNF-induced bowel lesions are indistinguishable from those caused by PAF. The mechanism of TNF-induced bowel necrosis is unclear. In the present study, we have shown that (a) TNF caused PAF production in bowel tissue; (b) the effects of TNF and LPS on PAF production in the intestine are additive; (c) TNF and LPS are synergistic in inducing bowel necrosis; and (d) TNF-induced bowel necrosis is due to PAF release and can be prevented by pretreatment with PAF antagonists. |
| |
| Keywords: | |
|
|
