Long‐term health‐related quality of life in drug‐resistant temporal lobe epilepsy after anterior temporal lobectomy |
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| Authors: | Chien‐Chen Chou Yang‐Hsin Shih Der‐Jen Yen Shang‐Yeong Kwan Hsiang‐Yu Yu |
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| Affiliation: | 1. Department of NeurologyNeurological Institute, Taipei Veterans General Hospital;2. Department of NeurologySchool of Medicine, National Yang‐Ming University;3. Department of NeurosurgeryNeurological Institute, Taipei Veterans General Hospital;4. Department of Neurosurgery, School of Medicine, National Yang‐Ming University, Taipei, Taiwan |
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| Abstract: | Epilepsy surgery is beneficial to patients suffering from drug‐resistant temporal lobe epilepsy in the short term, but fewer reports of long‐term outcomes have been published. To clarify the long‐term outcomes of seizure control and health‐related quality of life after epilepsy surgery, we enrolled 48 patients suffering from drug‐resistant temporal lobe epilepsy. All of the patients received comprehensive presurgical evaluations, including the Quality of Life in Epilepsy Inventory‐89 (QOLIE‐89) questionnaire to measure their health‐related quality of life. Among the patients, 28 patients received surgery (surgical group) and 20 patients remained under medication (medical group). Eight years later, the seizure frequency and QOLIE‐89 were evaluated. The seizure‐free rate was much higher in the surgical group (53.6%) than in the medical group (5%), eight years after the initial evaluation. The follow‐up QOLIE‐89 score was significantly higher in the surgical group than in the medical group. Moreover, the seizure frequency inversely correlated to the QOLIE‐89 score, regardless of the treatment group. Our results provide evidence that epilepsy surgery confers benefits with respect to seizure control and health‐related quality of life for drug‐resistant temporal lobe epilepsy patients based on long‐term follow‐up. |
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| Keywords: | temporal lobe epilepsy drug‐resistant epilepsy anterior temporal lobectomy epilepsy surgery seizure outcome quality of life |
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