| 基于无菌动物研究肠道微生物与类风湿关节炎发病相关性 |
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| 引用本文： | 惠彩霞,曾本华,刘晓飞,魏泓,方勇飞. 基于无菌动物研究肠道微生物与类风湿关节炎发病相关性[J]. 实验动物与比较医学, 2017, 25(6): 667-670,675 |
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| 作者姓名： | 惠彩霞 曾本华 刘晓飞 魏泓 方勇飞 |
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| 作者单位： | 第三军医大学西南医院中西医结合科与风湿免疫中心, 重庆 400038,第三军医大学基础部实验动物学教研室, 重庆 400038,第三军医大学西南医院中西医结合科与风湿免疫中心, 重庆 400038,第三军医大学基础部实验动物学教研室, 重庆 400038,第三军医大学西南医院中西医结合科与风湿免疫中心, 重庆 400038 |
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| 基金项目： | 国家自然科学基金面上项目（No.81072921）。 |
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| 摘 要： | 肠道微生物与宿主的生长发育、免疫、代谢等方面均密切相关，但肠道菌群与宿主之间复杂的相互作用在很大程度上仍然是未知的。目前无菌动物已成为探索肠道微生物与宿主相互作用的重要工具，多项研究使用无菌动物模型探讨肠道菌群在宿主代谢、机体免疫系统的发育和成熟等方面的作用，其中包括肠道菌群在自身免疫性疾病发病及预后中的作用。研究发现，肠道菌群作为环境因素之一可能参与类风湿关节炎（rheumatoid arthritis，RA）发病，然而其因果关系未明。本文将对使用无菌动物探讨肠道微生物参与类风湿关节炎发病的相关性研究作一综述，为进一步深入研究肠道菌群在RA发病中的作用及机制研究提供理论依据。
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| 关 键 词： | 无菌动物 肠道菌群 类风湿关节炎 免疫 动物模型 |
| 收稿时间： | 2017-09-10 |
Germ-free animal as a model to study the role of gut microbiotain the pathogenesis of rheumatoid arthritis |
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| HUI Cai-xi,ZENG Ben-hu,LIU Xiao-fei,WEI Hong and FANG Yong-fei. Germ-free animal as a model to study the role of gut microbiotain the pathogenesis of rheumatoid arthritis[J]. Laboratory Animal and Comparative Medicine, 2017, 25(6): 667-670,675 |
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| Authors: | HUI Cai-xi ZENG Ben-hu LIU Xiao-fei WEI Hong FANG Yong-fei |
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| Affiliation: | Department of Integrated Medicine and Rheumatology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China,Department of Experimental Animal Sciences, Third Military Medical University, Chongqing 400038,Department of Integrated Medicine and Rheumatology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China,Department of Experimental Animal Sciences, Third Military Medical University, Chongqing 400038 and Department of Integrated Medicine and Rheumatology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China |
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| Abstract: | The relationship between intestinal microbiome and host growth and development,immunity,metabolism and other aspects is very close.But the complex interaction between intestinal microbiota and host is still largely unknown.At present,germ-free animal models have become an important tool for exploring the interaction between intestinal microbiome and host.Many studies used germ-free animal models to explore the role of gut microbiome in host metabolism,the development of the immune system,including the role of gut microbiome in the pathogenesis and prognosis of autoimmune diseases.It has been found that intestinal microbiome as one of the environmental factors may be involved in the pathogenesis of rheumatoid arthritis,but its causal relationship is unknown.This paper will review the correlation between the intestinal microbiota and pathogenesis of rheumatoid arthritis by using germ-free animal models,and provide a theoretical basis for further study of the role of intestinal microbiome in the pathogenesis of rheumatoid arthritis. |
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| Keywords: | Germ-free animal Gut microbiome Rheumatoid arthritis Immunity Animal models |
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